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11-keto Fluprostenol Sale

(Synonyms: 曲伏前列素杂质) 目录号 : GC41880

A prostaglandin D2/Fluprostenol structural hybrid

11-keto Fluprostenol Chemical Structure

Cas No.:62145-07-7

规格 价格 库存 购买数量
1mg
¥994.00
现货
5mg
¥4,471.00
现货
10mg
¥7,950.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.

Chemical Properties

Cas No. 62145-07-7 SDF
别名 曲伏前列素杂质
Canonical SMILES O[C@@H](C1)[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)C1=O
分子式 C23H27F3O6 分子量 456.5
溶解度 PBS (7.2): 29 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.1906 mL 10.9529 mL 21.9058 mL
5 mM 0.4381 mL 2.1906 mL 4.3812 mL
10 mM 0.2191 mL 1.0953 mL 2.1906 mL
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Research Update

Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility

Eur J Pharmacol 2008 Feb 26;581(1-2):185-90.PMID:18177857DOI:10.1016/j.ejphar.2007.11.041.

Prostaglandins are bioactive lipids and important mediators of uterine relaxation as well as contraction during pregnancy and labour. E series prostaglandins may directly contract or relax myometrium in a dose-dependent manner, with the relaxatory effects mediated through the prostanoid receptors EP(2) and EP(4). The aim of this study was to evaluate the pharmacological effects of prostaglandin analogues on isolated pregnant rat uterine contractility, at 10(-15) to 10(-9) M concentrations. Uterine strips from rats at 19 days of gestation were set up in organ baths at 37 degrees C, bathed in Krebs buffer and gassed with 95% O(2)/5% CO(2). Spontaneous contractions were recorded via a force transducer. Concentration ranges of 10(-15)-10(-9) M of PGE(2), PGF(2alpha) and a range of prostaglandin analogues were applied non-cumulatively to the tissues. Spontaneous contractions were recorded for 12 min post dose. Amplitude, frequency, baseline tone and percent contractility over 10 min periods were analysed. PGE(2), butaprost, 9-keto fluprostenol, 11-keto Fluprostenol, 9-keto fluprostenol isopropyl ester, AL8810 and 15(S)-15-methyl PGE(2) all caused a decrease in percent contractility (P<0.05). These agents, plus Delta(12)PGJ(2) and 9-deoxy-9-methylene-16,16-dimethyl PGE(2), also decreased frequency of contraction (P<0.05). Only PGE(2), PGF(2alpha) and 11-keto Fluprostenol decreased baseline tone (P<0.05). The lower concentrations of prostaglandins used here mediated inhibition of spontaneous contractility of pregnant rat myometrium. Use of selective agonists suggested that the prostanoid receptors EP(2) and DP(2) are responsible for this relaxatory effect.