3-(4-Hydroxyphenyl)-1-propanol
(Synonyms: 3-(4-羟基苯基)-1-丙醇,Dihydro-p-coumaryl alcohol; 3-(p-Hydroxyphenyl)propyl alcohol) 目录号 : GC60489
3-(4-Hydroxyphenyl)-1-propanol is a reagent in the synthesis of (?)-Centrolobine, which is an anti-Leishmania agent.
Cas No.:10210-17-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >96.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
3-(4-Hydroxyphenyl)-1-propanol is a reagent in the synthesis of (?)-Centrolobine, which is an anti-Leishmania agent.
| Cas No. | 10210-17-0 | SDF | |
| 别名 | 3-(4-羟基苯基)-1-丙醇,Dihydro-p-coumaryl alcohol; 3-(p-Hydroxyphenyl)propyl alcohol | ||
| Canonical SMILES | OCCCC1=CC=C(O)C=C1 | ||
| 分子式 | C9H12O2 | 分子量 | 152.19 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.5707 mL | 32.8537 mL | 65.7073 mL |
| 5 mM | 1.3141 mL | 6.5707 mL | 13.1415 mL |
| 10 mM | 0.6571 mL | 3.2854 mL | 6.5707 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Hydrogen Borrowing: towards Aliphatic Tertiary Amines from Lignin Model Compounds Using a Supported Copper Catalyst
ChemSusChem 2022 Oct 10;15(19):e202200868.PMID:35900053DOI:10.1002/cssc.202200868.
Upcoming biorefineries, such as lignin-first provide renewable aromatics containing unique aliphatic alcohols. In this context, a Cu-ZrO2 catalyzed hydrogen borrowing approach was established to yield tertiary amine from the lignin model monomer 3-(3,4-dimethoxyphenyl)-1-propanol and the actual lignin-derived monomers, (3-(4-Hydroxyphenyl)-1-propanol and dihydroconiferyl alcohol), with dimethylamine. Various industrial metal catalysts were evaluated, resulting in nearly quantitative mass balances for most catalysts. Identified intermediates, side and reaction products were placed into a corresponding reaction network, supported by kinetic evolution experiments. Cu-ZrO2 was selected as most suitable catalyst combining high alcohol conversion with respectable aliphatic tertiary amine selectivity. Low pressure H2 was key for high catalyst activity and tertiary amine selectivity, mainly by hindering undesired reactant dimethylamine disproportionation and alcohol amidation. Besides dimethylamine model, diverse secondary amine reactants were tested with moderate to high tertiary amine yields. As most active catalytic site, highly dispersed Cu species in strong contact with ZrO2 is suggested. ToF-SIMS, N2 O chemisorption, TGA and XPS of spent Cu-ZrO2 revealed that imperfect amine product desorption and declining surface Cu lowered the catalytic activity upon catalyst reuse, while thermal reduction readily restored the initial activity and selectivity demonstrating catalyst reuse.
Phenylpropanoids as attractants for adult Stomoxys calcitrans (Diptera:Muscidae)
J Med Entomol 1996 Sep;33(5):859-62.PMID:8840698DOI:10.1093/jmedent/33.5.859.
Rate of capture of stable flies, Stomoxys calcitrans (L.), on phenylpropanoid-baited and unbaited sticky traps was determined in tests conducted in a corn field and in grasses adjacent to a dairy farm. Phenylpropanoid compounds significantly increased capture in 2 of 4 tests in corn. Captures were highest with 3-phenyl-1-propanol, followed closely by hydrocinnamaldehyde (3-phenyl-1-propanal), and more distantly by cinnamyl alcohol. Both sexes were trapped, although males predominated approximately 2:1. Compounds without apparent attractiveness were (E)-cinnamaldehyde, 4-propylphenol, and 3-(4-Hydroxyphenyl)-1-propanol. In the test adjacent to a dairy, 3-phenyl-1-propanol attracted approximately 16 times more stable flies than did 3-(4-Hydroxyphenyl)-1-propanol or controls. The latter 2 treatments did not differ from one another, but were significantly less effective than 3-phenyl-1-propanol, which captured 1.2 times more males than females. The results are discussed in relation to stable fly nectar- and host-seeking behaviors.
Versatile Manganese Catalysis for the Synthesis of Poly(silylether)s from Diols and Dicarbonyls with Hydrosilanes
ACS Omega 2017 Feb 16;2(2):582-591.PMID:31457456DOI:10.1021/acsomega.6b00538.
Poly(silylether)s are interesting materials because of their degradation property under hydrolytic conditions and have been prepared via hydrosilylation polymerization from dicarbonyl and hydrosilanes, and via dehydrogenative cross-coupling of diols and hydrosilanes under catalytic conditions. Here, we present a manganese-salen compound based on an inexpensive and nontoxic metal that could effectively catalyze both polymerization reactions with hydrosilane. A series of poly(silylether)s containing various aliphatic and aromatic backbones have been synthesized from diol and dicarbonyl substrates. Moderate to high yields of polymers with number-average molecular weights up to 15 kg/mol are obtained. Because of the dual activity of the manganese catalyst, unsymmetrical substrates with mixed functional groups, such as p-hydroxybenzaldehyde, p-hydroxy benzylalcohol, and 3-(4-Hydroxyphenyl)-1-propanol, have been employed to afford poly(silylether)s with multiple silicon connectivity in the main chain.