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Rufinamide Sale

(Synonyms: 卢非酰胺; CGP 33101; E 2080; RUF 331) 目录号 : GC13792

An anticonvulsant

Rufinamide Chemical Structure

Cas No.:106308-44-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥357.00
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10mg
¥357.00
现货
25mg
¥672.00
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100mg
¥1,880.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).IC50 Value:Target: in vitro:in vivo: Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively).Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD). Phase 2

References:
[1]. Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72.
[2]. White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20.

Chemical Properties

Cas No. 106308-44-5 SDF
别名 卢非酰胺; CGP 33101; E 2080; RUF 331
化学名 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide
Canonical SMILES C1=CC(=C(C(=C1)F)CN2C=C(N=N2)C(=O)N)F
分子式 C10H8F2N4O 分子量 238.19
溶解度 ≥ 11.25mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.1983 mL 20.9916 mL 41.9833 mL
5 mM 0.8397 mL 4.1983 mL 8.3967 mL
10 mM 0.4198 mL 2.0992 mL 4.1983 mL
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