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PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

  1. Cat.No. Product Name Information
  2. GC62450 (S)-PI3Kα-IN-4 (S)-PI3Kα-IN-4 是一种有效的 PI3Kα 抑制剂,IC50 为 2.3 nM。(S)-PI3Kα-IN-4 对 PI3Kα 的选择性分别比 PI3Kβ,PI3Kδ 和 PI3Kγ 高38.3,4.25 和 4.93 倍。(S)-PI3Kα-IN-4 可用于癌症的研究。
  3. GC35037 1,3-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物,具有抗氧化活性和自由基清除活性。
  4. GC41992 1-Deoxynojirimycin (hydrochloride) 1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II.
  5. GC10710 3-Methyladenine Class III PI3K inhibitor
  6. GC16157 740 Y-P PI 3-kinase activator,cell permeable
  7. GC17550 A66 P110α inhibitor
  8. GC10860 Acalisib (GS-9820) PI3Kδ inhibitor
  9. GC13913 AMG319 PI3Kδ inhibitor
  10. GC35395 Arnicolide D Arnicolide D 是一种从石胡荽 (Centipeda minima) 中分离出倍半萜内酯。Arnicolide D 调节细胞周期,激活 caspase 信号通路,并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。Arnicolide D 以剂量和时间依赖性方式显着抑制鼻咽癌 (NPC) 细胞生长。
  11. GC11910 AS-041164 PI3Kγ inhibitor
  12. GC13901 AS-252424 PI3Kγ inhibitor,novel and potent
  13. GC12080 AS-604850 PI3Kγ inhibitor,selective and ATP-competitve
  14. GC12474 AS-605240 Potent and selective PI 3-Kγ inhibitor
  15. GC62335 AZ2 AZ2 是一种高度选择性的 PI3Kγ 抑制剂(PI3Kγ 的 pIC50 为 9.3)。AZ2 可用于炎症和免疫疾病的研究。
  16. GC16851 AZD6482

    PI3Kβ inhibitor,potent and selective

  17. GC12576 AZD8186 Potent and selective inhibitor of PI3Kβ and PI3Kδ
  18. GC11248 AZD8835 PI3Kα and PI3Kδ inhibitor
  19. GC17766 BAY 80-6946 (Copanlisib) PI3K inhibitor
  20. GC62164 BAY1082439 BAY1082439 是一种具有口服活性的,选择性 PI3Kα/β/δ 抑制剂。BAY1082439 也能抑制 PIK3CA 的突变形式,BAY1082439 对抑制 Pten 丢失的前列腺癌的生长有很强的作用。
  21. GC33145 BEBT-908 (PI3Kα inhibitor 1) BEBT-908是一种选择性的PI3Kα抑制剂,IC50<0.1μM,也抑制HDAC(0.1μM≤IC50≤1μM),详细信息请参考专利文献US/20120088764A1中的化合物243。

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