| ML-162 目录号 GC44214 |
Sample solution is provided at 25 µL, 10mM.
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Purity = 95.00%
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| Cas No. | 1035072-16-2 | SDF | Download SDF |
| 别名 | N/A | ||
| 化学名 | α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide | ||
| Canonical SMILES | O=C(C(N(C(CCl)=O)C1=CC=C(OC)C(Cl)=C1)C2=CC=CS2)NCCC3=CC=CC=C3 | ||
| 分子式 | C23H22Cl2N2O3S | 分子量 | 477.4 |
| 溶解度 | 1mg/mL in ethanol, 25mg/ml in DMSO, 10mg/mL in DMF | 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).[1],[2] It shares a similar structure but is more potent and selective than (1S,3R)-RSL3, a previously reported inhibitor of RAS oncogene-expressing cells.[2]
Reference:
[1]. Yang, W.S., and Stockwell, B.R. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26(3), 165-176 (2016).
[2]. Weïwer, M., Bittker, J.A., Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).