| Infliximab 目录号 GC19533 |
Sample solution is provided at 25 µL, 10mM.
| Cas No. | 170277-31-3 | SDF | Download SDF |
| 别名 | N/A | ||
| 化学名 | N/A | ||
| Canonical SMILES | N/A | ||
| 分子式 | C6428H9912N1694O1987S46 | 分子量 | 144188.23 |
| 溶解度 | N/A | 储存条件 | Store at -30°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Infliximab neutralizes the biological activity of TNF-α by binding with high affinity to the soluble (free floating in the blood) and transmembrane (located on the outer membranes of T cells and similar immune cells) forms of TNF-α, and inhibits or prevents the effective binding of TNF-α with its receptors. Infliximab has high specificity for TNF-α, and does not neutralize TNF beta. Infliximab prevents disease in transgenic mice (a special type of mice biologically engineered to produce a human form of TNF-α and which are used to test the results of these drugs that might be expected in humans).
References:
[1].Promising biological therapies for ulcerative colitis: A review of the literature.
Akiho H, et al. World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):219-27. PMID: 26600980.
[2].Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.
Keane J, et al. N Engl J Med. 2001 Oct 11;345(15):1098-104. PMID: 11596589.