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(+)-Borneol Sale

(Synonyms: (+)-冰片) 目录号 : GC34954

A bicyclic monoterpene with diverse biological activities

(+)-Borneol Chemical Structure

Cas No.:464-43-7

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Free Sample (0.1-0.5 mg) 待询 待询
10mM (in 1mL DMSO)
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100mg
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产品描述

(+)-Borneol is a bicyclic monoterpene and a stereoisomer of (–)-borneol that has been found in various plants, including S. tomentosa, and has diverse biological activities including analgesic, neuroprotective, antioxidant, and antimicrobial properties.1,2,3,4 (+)-Borneol is a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors (EC50 = 248 μM for human recombinant receptors).1 It dose-dependently increases the paw withdrawal threshold following segmental spinal nerve ligation surgery or intraplantar injection of complete Freund's adjuvant (CFA) in mouse paw.2 (+)-Borneol (100 μM) inhibits increases in reactive oxygen species (ROS) levels and cytotoxicity in SH-SY5Y neuroblastoma cells incubated with amyloid-β (1-42) .3 It also inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including E. coli, S. aureus, P. aeruginosa, P. vulgaris, and S. typhimurium (MICs = 125-250 μg/mL).4 Formulations containing (+)-borneol have been used as fragrance ingredients.

1.Granger, R.E., Campbell, E.L., and Johnston, G.A.R.(+)- And (–)-borneol: Efficacious positive modulators of GABA action at human recombinant α1β2γ2L GABAA receptorsBiochem. Pharmacol.69(7)1101-1111(2005) 2.Jiang, J., Shen, Y.Y., Li, J., et al.(+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in miceEur. J. Pharmacol.75753-58(2015) 3.Hur, J., Pak, S.C., Koo, B.S., et al.Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cellsPharm. Biol.51(1)30-35(2013) 4.Tabanca, N., Kirimer, N., Demirci, B., et al.Composition and antimicrobial activity of the essential oils of Micromeria cristata subsp. phrygia and the enantiomeric distribution of borneolJ. Agric. Food Chem.49(9)4300-4303(2001)

Chemical Properties

Cas No. 464-43-7 SDF
别名 (+)-冰片
Canonical SMILES O[C@@H]1[C@](C2(C)C)(C)CC[C@]2([H])C1
分子式 C10H18O 分子量 154.25
溶解度 DMSO: ≥ 100 mg/mL (648.30 mM); Water: < 0.1 mg/mL (insoluble) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 6.483 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.483 mL 12.966 mL
10 mM 0.6483 mL 3.2415 mL 6.483 mL
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