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Endothelin-1 (1-15), amide, human

目录号 GP10062

Vasoconstrictor agent

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Sample solution is provided at 25 µL, 10mM.


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Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium and have a key role in vascular homeostasis. Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC. [1]

Endothelins constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure (hypertension) and heart disease.

Endothelins are the most potent vasoconstrictors known. [2] In a healthy individual, a delicate balance between vasoconstriction and vasodilation is maintained by endothelin and other vasoconstrictors as well as nitric oxide, prostacyclin and other vasodilators. The ubiquitous distribution of endothelin peptides and receptors implicates its involvement in a wide variety of physiological and pathological processes in the body. Among numerous diseases potentially occurring from endothelin dysregulation are: several types of cancer [3], cerebral vasospasm following subarachnoid hemorrhage, arterial hypertension and other cardiovascular disorder, pain mediation, type II diabetes, etc.

1. Medical physiology a cellular and molecular approach (2nd ed., International ed. ed.). Philadelphia, PA: Saunders/Elsevier. 2009. pp. 480.
2. Modern pharmacology with clinical applications (6th ed. ed.). Philadelphia: Lippincott Williams & Wilkins. 2004. pp. 215.
3. Bagnato A, Rosanò L (2008). "The endothelin axis in cancer". Int. J. Biochem. Cell Biol. 40 (8): 1443–51.

Chemical Properties

Cas No. N/A SDF
别名 H2N-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-NH2
化学名 N/A
Canonical SMILES N/A
分子式 C70H109N17O23S5 分子量 1717.04
溶解度 Soluble in water or 1% acetic acid 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
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*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。