VAV1 Human
目录号 : GP24981Vav 1 Guanine Nucleotide Exchange Factor Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 85% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Vav 1 Guanine Nucleotide Exchange Factor; VAV; Vav 1Oncogene; Proto-Oncogene Vav. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMTEYDKR CCCLREIQQT EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEIIFINIEDLLR VHTHFLKEMK EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD RVAAAREDVQMKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQSLAHYGRPKI DGELKITSVE RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR DDSSGDRDNKKWSHMFLLIE DQGAQGYELF FKTRELKKKW MEQFEMAISN IYPENATANG HDFQMFSFEE TTSCKACQML LRGTFYQGYR CHRCRASAHK ECLGRVPPCG | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | VAV1 protein solution (0.25mg/ml) containing In 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 30%glycerol and 2mM DTT. | ||
Vav1 Guanine Nucleotide Exchange Factor (VAV1), belongs to the VAV gene family.The VAV1 proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases whichactivate pathways leading to actin cytoskeletal rearrangements and transcriptionalalterations. VAV1 is essential in hematopoiesis, taking part in T-cell andB-cell development and activation. VAV1 has been identified as the specificbinding partner of Nef proteins from HIV-1. In addition, VAV1 contains an SH2domain, which could show its function as a substrate for tyrosine kinases. Expressionof VAV1 is limited solely to cells of hematopoietic origin, as well as those ofthe erythroid, lymphoid and myeloid lineages. Among the diseases associatedwith VAV1 are cherubism, and hiv-1.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.