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Thiostrepton Sale

(Synonyms: 硫链丝菌素) 目录号 : GC13002

An inhibitor of FoxM1

Thiostrepton Chemical Structure

Cas No.:1393-48-2

规格 价格 库存 购买数量
50mg
¥441.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Thiazole antibiotic thiostrepton is an inhibitor of Forkhead box M1 (FOXM1), which effectively reduces cancer cell growth through downregulation of FOXM1. FOXM1 is a transcription factors that regulate expression of genes involved in maintenance of genomic stability and cell cycle progression.

In vitro: Thiostrepton inhibits the transcriptional activity and FOXM1 expression, and induces strong apoptosis in human cancer cells of different origin that correlates with suppression of FOXM1, including leukemia, neuroblastoma, liver cancer, melanoma and prostate cancer cells. Thiostrepton binds FOXM1 on the promoter site to inhibit transcriptional activity of FOXM1 through the FOXM1 autoregulation mechanism [1].

In vivo: Thiostrepton suppressed tumor growth in a human breast cancer xenograft model. Treatment with developed micelle-thiostrepton nanoparticles decreased xenograft tumor growth induced by the human MDA-MB-231 breast and HepG2 liver cancer cell lines. These apoptosis activities in drug-treated tumors were correlated with in vivo suppression of oncogenic FOXM1 [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Gartel AL.  Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors. Scientifica (Cairo). 2014;2014:596528.

Chemical Properties

Cas No. 1393-48-2 SDF
别名 硫链丝菌素
分子式 C72H85N19O18S5 分子量 1664.89
溶解度 2mg/ml in DMSO, 25mg/mL in DMF 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.6006 mL 3.0032 mL 6.0064 mL
5 mM 0.1201 mL 0.6006 mL 1.2013 mL
10 mM 0.0601 mL 0.3003 mL 0.6006 mL
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