Thiamethoxam
(Synonyms: 噻虫嗪) 目录号 : GC39452
A neonicotinoid insecticide
Cas No.:153719-23-4
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Thiamethoxam is a neonicotinoid insecticide and a precursor to the neonicotinoid insecticide clothianidin.1,2 It binds to nicotinic acetylcholine receptors with low affinity (nAChRs; IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM).2 Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, N. lugens, and S. littoralis when administered in contact/feeding assays (LC80s = 12, 3, 0.8, and 3 mg AI/L, respectively) and via systemic administration (LC80s = 0.8, 0.2, 0.05, and 0.8 mg AI/L, respectively) as well as D. balteata in a contact/feeding assay (LC50 = 0.8 mg AI/L).1 Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L.2 Formulations containing thiamethoxam have been used in the control of insects in agriculture.
1.Maienfisch, P., Huerlimann, H., Rindlisbacher, A., et al.The discovery of thiamethoxam: A second-generation neonicotinoidPest. Manag. Sci.57(2)165-176(2001) 2.Nauen, R., Ebbinghaus-Kintscher, U., Salgado, V.L., et al.Thiamethoxam is a neonicotinoid precursor converted to clothianidin in insects and plantsPest. Biochem. Phys.76(2)55-69(2003)
| Cas No. | 153719-23-4 | SDF | |
| 别名 | 噻虫嗪 | ||
| Canonical SMILES | O=[N+](/N=C1N(CC2=CN=C(Cl)S2)COCN/1C)[O-] | ||
| 分子式 | C8H10ClN5O3S | 分子量 | 291.71 |
| 溶解度 | DMSO: 250 mg/mL (857.02 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4281 mL | 17.1403 mL | 34.2806 mL |
| 5 mM | 0.6856 mL | 3.4281 mL | 6.8561 mL |
| 10 mM | 0.3428 mL | 1.714 mL | 3.4281 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Thiamethoxam intoxication due to occupational inhalational exposure
BMJ Case Rep 2022 Nov 29;15(11):e251110.PMID:PMC9710362DOI:10.1136/bcr-2022-251110.
Neonicotinoid is a new class of systemic insecticides that are selectively toxic to insects. However, cases of human toxicity have been reported. A man in his 60s, who worked as a pest control operator (which required the use of Thiamethoxam), presented with fever and headache. We investigated the levels of Thiamethoxam and clothianidin in the blood and urine. Our results suggested that chronic Thiamethoxam intoxication was caused by occupational inhalation exposure and environmental pollution. After cessation of insecticide use, the patient remained asymptomatic but had persistent oral dysesthesia and postural finger tremor, even at undetectable levels of Thiamethoxam and clothianidin. This case report is the first to describe human Thiamethoxam intoxication after occupational inhalation exposure. When similar symptoms are encountered and a history of insecticide use is confirmed, clinicians should consider the diagnosis of neonicotinoid intoxication.
Embryonic Exposure to Thiamethoxam Reduces Survival and Alters Neurobehavior of Fathead Minnows
Environ Toxicol Chem 2022 May;41(5):1276-1285.PMID:35099087DOI:10.1002/etc.5301.
Thiamethoxam is a commonly used neonicotinoid insecticide that acts as a nicotinic acetylcholine receptor (nAChR) agonist. Although vertebrates are less sensitive to neonicotinoid insecticides than invertebrates, some neonicotinoids have been shown to cause neurobehavioral changes in larval fishes. In the present study, we examine the neurobehavioral toxicity of acute and chronic exposure to environmentally relevant concentrations of Thiamethoxam in fathead minnows at two different life stages. Whereas acute exposure of embryos to Thiamethoxam does not appear to stimulate spontaneous contractions within 1 min, chronic exposure of embryos to 1.57 µg or more Thiamethoxam/L caused increased mortality as well as a subtle increase in spontaneous contraction frequency (SCF), which was negatively correlated with early hatching success. Chronic exposure of embryos to 155 µg Thiamethoxam/L impaired predator escape response, and chronic exposure to 0.02-14.61 µg Thiamethoxam/L impaired foraging efficiency of some fish. Fathead minnows exposed to Thiamethoxam beginning post hatch did not experience changes to measured health or neurobehavioral indicators. Taken together, our findings indicate that embryonic life stages are more sensitive to Thiamethoxam exposure than later larval life stages. Because early exposure to Thiamethoxam can cause deficits in predatory escape behaviors and may impair foraging success, further study of the potential direct and nondirect impacts of Thiamethoxam on wild fish populations is warranted. Environ Toxicol Chem 2022;41:1276-1285. © 2022 SETAC.
Acute toxic effects of Thiamethoxam on Chinese mitten crab Eriocheir sinensis
Environ Sci Pollut Res Int 2022 Sep;29(42):63512-63519.PMID:35460484DOI:10.1007/s11356-022-20294-y.
The information about toxic effects of Thiamethoxam on non-target aquatic organisms is still incomplete. The semi-static toxicity test method was used to investigate the acute toxic effects of Thiamethoxam on Eriocheir sinensis. The results showed that the median lethal concentration (LC50) of Thiamethoxam to E. sinensis at 96 h was 510 μg/L, and the safety concentration (SC) was 51 μg/L. After 96 h exposure to Thiamethoxam, the survival rates of crabs at concentrations of 0, 151.11, 226.67, 340, and 510 μg/L were 100%, 76.19%, 64.29%, 61.91%, and 46.43%, respectively. A significant (P < 0.05) decrease of the number of hemocytes was observed in Thiamethoxam groups. With the increase of Thiamethoxam concentration, the phagocytic activity of hemocytes, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), and the activities of protease, amylase, and lipase of crabs increased firstly and then decreased, and the above indexes reached the maximum in 151.11 μg/L Thiamethoxam group. Collectively, a high concentration of Thiamethoxam (510 μg/L) had a great effect on the gene expression of immune metabolism-related factors in hepatopancreas and gill of crabs. These findings indicated that Thiamethoxam exposure had the ability to impair immune and metabolic systems and resulted in the reduction of survival rate of crabs.
Phytotonic effects of Thiamethoxam on sugarcane managed with glyphosate as a ripener
Pest Manag Sci 2022 Oct;78(10):4006-4017.PMID:35645152DOI:10.1002/ps.7019.
Background: Thiamethoxam and glyphosate are widely used in sugarcane production as an insecticide and ripener, respectively. In this study, the potential of these chemical products to also elicit phytotonic effects and enhance the physiological development and yield of sugarcane was evaluated. In field experiments, Thiamethoxam and glyphosate were applied to sugarcane individually or in combination, and the effects of these chemical management strategies on sugarcane biometric and technological parameters were assessed. Results: Thiamethoxam application improved biometric parameters, especially stalk yield. Glyphosate application increased sugar yield, despite reducing the number of stalks and consequently the stalk yield. Conclusions: Application of the insecticide Thiamethoxam to sugarcane attenuates the depreciative effect of ripener (glyphosate) and has a potential phytotonic effect by increasing sugar yields in the early and late seasons. © 2022 Society of Chemical Industry.
The fate of Thiamethoxam and its main metabolite clothianidin in peaches and the wine-making process
Food Chem 2022 Jul 15;382:132291.PMID:35152030DOI:10.1016/j.foodchem.2022.132291.
Thiamethoxam is widely used to control a large number of insect pests of peach crops. Understanding the fate of Thiamethoxam and its main metabolite clothianidin in field peach, during storage, and in the processing of peach wine is of vital importance for food safety. The Thiamethoxam and clothianidin were separated and determined by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). Field and storage results showed that the half-lives of Thiamethoxam were 4.9-5.5 and 10.3-15.8 days, respectively. The processing factors (PFs) of all the wine-making procedures were less than 1, and the PFs of the overall process ranged from 0.10 to 0.47. The highest elimination rate was obtained for Thiamethoxam and clothianidin during the fermentation process. The results from this study could understand the dissipation kinetics and residual levels of Thiamethoxam and clothianidin in peach, and also help to accurately assess their risks in the raw and wine-making process.