Thiacloprid
(Synonyms: 噻虫啉) 目录号 : GC48164
A neonicotinoid insecticide
Cas No.:111988-49-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50 values of 2.7 and 860 nM for Drosophila nAChRs and M10 mouse fibroblast cells expressing α4β2 subunit-containing nAChRs, respectively.1 It is active against aphids, whiteflies, various species of beetle, and Lepidoptera species when used at concentrations ranging from 48 to 180 g AI/hectare.2 It has anti-estrogenic activity in a yeast estrogen screen and is toxic to adult female houseflies and mice (LD50s = 0.03 and 28 mg/kg, respectively).1,3 Formulations containing thiacloprid have been used in the control of insects in agriculture.
1.Tomizawa, M., and Casida, J.E.Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptorsAnnu. Rev. Entomol.48339-364(2003) 2.Elbert, A., Erdelen, C., Kuhnhold, J., et al.Thiacloprid, a novel neonicotinoid insecticide for foliar applicationProc. Brighton Crop. Prot. Conf. - Pests and Diseases121-26(2000) 3.Westlund, P., and Yargeau, V.Investigation of the presence and endocrine activities of pesticides found in wastewater effluent using yeast-based bioassaysSci. Total Environ.607-608744-751(2017)
| Cas No. | 111988-49-9 | SDF | |
| 别名 | 噻虫啉 | ||
| Canonical SMILES | ClC(C=C1)=NC=C1CN2CCS/C2=N\C#N | ||
| 分子式 | C10H9ClN4S | 分子量 | 252.7 |
| 溶解度 | Chloroform: Slightly Soluble,Methanol: Slightly Soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9573 mL | 19.7863 mL | 39.5726 mL |
| 5 mM | 0.7915 mL | 3.9573 mL | 7.9145 mL |
| 10 mM | 0.3957 mL | 1.9786 mL | 3.9573 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Thiacloprid Detection by Silver Nanocubes-Based SERS Sensor
IEEE Trans Nanobioscience 2022 Jan;21(1):141-143.PMID:34329168DOI:10.1109/TNB.2021.3101187.
The use of neonicotinoid insecticides leads to environmental problems such as accumulation and death of different insects and even bird species. In this work, we compared the SERS performance of Ag nanocubes- and nanospheres-based substrates for the analysis of Thiacloprid, a neonicotinoid, reaching its detection at 1 mM using nanocubes as the active material.
Nitrile Hydratases: From Industrial Application to Acetamiprid and Thiacloprid Degradation
J Agric Food Chem 2021 Sep 15;69(36):10440-10449.PMID:34469128DOI:10.1021/acs.jafc.1c03496.
The widespread application of neonicotinoid insecticides (NEOs) in agriculture causes a series of environmental and ecological problems. Microbial remediation is a popular approach to relieve these negative impacts, but the associated molecular mechanisms are rarely explored. Nitrile hydratase (NHase), an enzyme commonly used in industry for amide production, was discovered to be responsible for the degradation of acetamiprid (ACE) and Thiacloprid (THI) by microbes. Since then, research into NHases in NEO degradation has attracted increasing attention. In this review, microbial degradation of ACE and THI is briefly described. We then focus on NHase evolution, gene composition, maturation mechanisms, expression, and biochemical properties with regard to application of NHases in NEO degradation for bioremediation.
Peer review of the pesticide risk assessment of the active substance Thiacloprid
EFSA J 2019 Mar 14;17(3):e05595.PMID:32626237DOI:10.2903/j.efsa.2019.5595.
The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State the United Kingdom and co-rapporteur Member State Germany for the pesticide active substance Thiacloprid are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of Thiacloprid as an insecticide on oilseed rape foliar use and maize seed treatment. The peer review also provided conclusions on whether exposure of humans to thiacoprid can be considered negligible, taking into account the European Commission's draft guidance on this topic. Confirmatory data following the review of existing maximum residue levels (MRLs) according to Article 12 of Regulation (EC) No 396/2005 were also assessed in this conclusion. The reliable end points, appropriate for use in regulatory risk assessment are presented. An evaluation of data concerning the necessity of Thiacloprid as an insecticide to control a serious danger to plant health which cannot be contained by other available means, including non-chemical methods is presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.
Genotoxicity of Thiacloprid in zebrafish liver
Arch Environ Occup Health 2023;78(3):152-157.PMID:36052857DOI:10.1080/19338244.2022.2118212.
Thiacloprid (TH), one of the most widely used pesticides in the world, might cause toxic effects like DNA damage in humans and animals due to their frequent use. Accordingly, this study investigated TH's potential DNA-damaging effects on zebrafish liver via alkaline comet assay. Two treatment groups of ten zebrafish each were exposed to TH at two different concentrations, 1.64 and 0.82 mg/L, for 21 days and compared with an untreated control group. After exposure, the fishes' liver tissues were excised, and an alkaline comet assay was performed. Two slides per sample and 50 cells per slide were assessed with a visual evaluation program. The average DNA Damage values of the control, 0.82 mg/L TH, and 1.64 mg/L TH groups were 4.37 ± 5.12, 8.51 ± 8.54, and 9.30 ± 9.99, respectively. Both TH treatment groups had statistically significantly more DNA damage than the control group (p < 0.001). When comparing the TH treatment groups alone, the 1.64 mg/L dose group featured greater damage than the 0.82 mg/L dose group (p < 0.05). TH therefore causes significant DNA damage to the liver in a dose-dependent manner, revealing it to be a genotoxic agent that should be further investigated.
Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish
Int J Environ Res Public Health 2022 Sep 1;19(17):10920.PMID:36078631DOI:10.3390/ijerph191710920.
As a major neonicotinoid insecticide, Thiacloprid (THCP) is frequently detected in aquatic environments worldwide due to its heavy use, posing potential threats to aquatic organisms. In this study, zebrafish (Danio rerio) embryos were exposed to THCP (1, 10, 100, 1000 and 10,000 μg/L) for 5 days and then recovered in THCP-free water for 20 days to investigate the effects of early-stage THCP exposure on the development, antioxidant defense, and neurotransmitter systems of zebrafish, and explore their recovery mechanism. The results show that THCP exposure induced developmental toxicity and oxidative stress in zebrafish. The hypoactivity, behavioral alterations (decreased avoidance and edge preference behaviors) and neurotoxicity were found throughout the exposure-recovery experiments. THCP exposure altered the expression of γ-aminobutyric acid (GABA)- and serotonin (5-HT)-related genes accompanied by the decrease in GABA and 5-HT contents. However, after recovery, GABA content returned to the control level, but 5-HT did not, indicating that only the serotonergic system was persistently disrupted. Overall, our results suggest that the disruption of the serotonergic system and oxidative stress may aggravate neurotoxicity and that the former was the main reason for the depressive-like behavior. This study could help to unravel the mechanisms of the behavioral alterations induced by early-stage THCP exposure in zebrafish.