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(Synonyms: 磺胺邻二甲氧嘧啶-D4,Sulphadoxine-d4) 目录号 : GC52174

An internal standard for the quantification of sulfadoxin

Sulfadoxin-d4 Chemical Structure

规格 价格 库存 购买数量
1 mg
5 mg

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Sample solution is provided at 25 µL, 10mM.


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Sulfadoxin-d4 is intended for use as an internal standard for the quantification of sulfadoxin by GC- or LC-MS. Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid synthesis.1 Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.2 Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum.2,3 Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).3

1.Brooks, D.R., Wang, P., Read, M., et al.Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxineEur. J. Biochem.224(2)397-405(1994) 2.Hyde, J.E.Exploring the folate pathway in Plasmodium falciparumActa. Trop.94(3)191-206(2005) 3.Wang, P., Read, M., Sims, P.F.G., et al.Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.Mol. Microbiol.23(5)979-986(1997)

Chemical Properties

Cas No. 1330266-05-1 SDF Download SDF
别名 磺胺邻二甲氧嘧啶-D4,Sulphadoxine-d4
Canonical SMILES O=S(NC1=NC=NC(OC)=C1OC)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])N)=O
分子式 C12H10D4N4O4S 分子量 314.4
溶解度 Acetone: soluble,DMSO: soluble,Methanol: soluble 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
% DMSO % % Tween 80 % ddH2O
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*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。