STh
(Synonyms: 热稳定毒素多肽) 目录号 : GC61489
STh，是一种大肠杆菌的热稳定毒素，是一种含有19个氨基酸的多肽，包含三个二硫键桥。STh是寻找广泛覆盖的产肠毒素大肠杆菌(ETEC)疫苗的抗原。
Cas No.:118447-40-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
STh, an Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide encompassing three disulfide bridges. STh is an antigen of interest in the search for a broad coverage enterotoxigenic Escherichia coli (ETEC) vaccine[1].
[1]. PÅl PUNTERVOLL, et al. Heat-stable enterotoxins mutants as antidiarrheal vaccine antigens. WO2020039387A1.
| Cas No. | 118447-40-8 | SDF | |
| 别名 | 热稳定毒素多肽 | ||
| 分子式 | C79H112N22O30S6 | 分子量 | 2042.25 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.4897 mL | 2.4483 mL | 4.8966 mL |
| 5 mM | 0.0979 mL | 0.4897 mL | 0.9793 mL |
| 10 mM | 0.049 mL | 0.2448 mL | 0.4897 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Post-intervention epidemiology of STh in Bangladesh: Data to sustain the gains
PLoS Negl Trop Dis 2020 Dec 7;14(12):e0008597.PMID:33284834DOI:10.1371/journal.pntd.0008597.
In 2008, Bangladesh initiated Preventive Chemotherapy (PCT) for school-age children (SAC) through bi-annual school-based mass drug administration (MDA) to control Soil-Transmitted Helminth (STh) infections. In 2016, the Ministry of Health and Family Welfare's Program on Lymphatic Filariasis Elimination and STh (ELFSTH) initiated district-level community impact assessments with Children Without Worms (CWW) using standardized, population-based sampling to measure the post-intervention STh burden across all ages (≥ 1 yr) for the three STh species. The Integrated Community-based Survey for Program Monitoring (ICSPM) was developed by CWW and was used to survey 12 districts in Bangladesh from 2017-2020. We excluded the first two district data as piloting caused some sampling errors and combined the individual demographic and parasite-specific characteristics from the subsequent 10 districts, linking them with the laboratory data for collective analysis. Our analysis identified district-specific epidemiologic findings, important for program decisions. Of the 17,874 enrolled individuals, our results are based on 10,824 (61.0%) stool samples. Overall, the prevalence of any STh species was substantially reduced to 14% from 79.8% in 2005. The impact was similar across all ages. STh prevalence was 14% in 10 districts collectively, but remained high in four districts, despite their high reported PCT coverage in previous years. Among all, Bhola district was unique because it was the only district with high T.trichuris prevalence. Bangladesh successfully lowered STh prevalence across all ages despite targeting SAC only. Data from the survey indicate a significant number of adults and pre-school age children (PSAC) were self-deworming with purchased pills. This may account for the flat impact curve across all ages. Overall prevalence varied across surveyed districts, with persistent high transmission in the northeastern districts and a district in the central flood zone, indicating possible service and ecological factors. Discrepancies in the impact between districts highlight the need for district-level data to evaluate program implementation after consistent high PCT coverage.
COMT and STh polymorphisms interaction on cognition in schizophrenia
Neurol Sci 2015 Feb;36(2):215-20.PMID:25283873DOI:10.1007/s10072-014-1936-9.
Catechol-O-methyltransferase (COMT) gene, a key regulator of prefrontal cortex (PFC) dopamine (DA) availability, has been extensively studied in relation to cognitive domains, mainly executive functions, that are impaired in schizophrenia, but results are still controversial. Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STh) gene as a concurring factor in hypofrontality, we hypothesize that STh and COMT polymorphisms could have an additive effect on cognition in schizophrenia. Three forty three clinically stabilized patients with schizophrenia were assessed with a broad neuropsychological battery including the Brief Assessment of Cognition in Schizophrenia, the Wisconsin Card Sorting Test and the Continuous Performance Test and were genotyped for COMT Val108/158Met and STh Q7R polymorphisms. We observed the effects of COMT on speed of processing and executive functions, as well as a significant effect of STh on executive functions performances. Moreover, a significant interaction between COMT and STh polymorphisms was found on executive functions, with COMT Val/Val and STh R carriers performing worse. Our results showed a significant interaction effect of COMT and STh polymorphisms on cognitive performances, strengthening the involvement of STh in cognitive impairments, especially in the domains commonly impaired in schizophrenia.
Risk factors associated with soil transmitted helminth (STh) infection in two indigenous communities in Malaysia
Trop Biomed 2020 Jun 1;37(2):379-388.PMID:33612807doi
Soil-transmitted helminth (STh) could possibly cause mild to severe health effects such as diarrhea, weakness, intestinal blood loss, and impaired cognitive development and growth. In Malaysia, previous studies depicted a high prevalence rate of STh was due to poor hygiene practice and low efficacies of anthelminthic drugs. This study was conducted to investigate hand hygiene practice and WASH criteria's (Water, sanitation and hygiene) related to STh infection among two indigenous tribes in Peninsular Malaysia. A cross-sectional study was carried out to study the relationship among STh infection compared to water quality, sanitation, and hygiene conditions. A total of 190 individuals from two indigenous villages participated in the study, with ages ranging from 5 to 60 years old. In addition, Pearson's Chisquare (X2) test was utilized to test the relationship among STh with demographic socioeconomic and behavioral factors. The confidence interval (CI) of 95% is used to estimate the precision of the odds ratio (OR). Multivariate logistic regression models were also used to identify the risk factors associated with STh infections. The overall findings indicated a prevalence rate of 72% for STh, and distributed mainly among children aged < 12 years. Furthermore, multivariate analyses using logistic regression revealed chronic health problems, incorrect hand washing, and walking bare footed were associated with STh infection. Overall results indicated high prevalence of STh among the indigenous villagers, which aligns with the published literature and proves to be a problem need to be addressed as neglected disease. Interestingly, there was a significant relationship between the presences of chronic diseases and STh infection, which prompted other questions the awareness needs to be educated and the simple and low-cost intervention on the proper way of hand washing may help to reduce STh infection in these indigenous communities.
Correction: Functional illiteracy burden in soil-transmitted helminth (STh) endemic regions of the Philippines: An ecological study and geographical prediction for 2017
PLoS Negl Trop Dis 2022 Jun 16;16(6):e0010553.PMID:35709077DOI:10.1371/journal.pntd.0010553.
[This corrects the article DOI: 10.1371/journal.pntd.0007494.].
[Subclinical thyroid disease]
Vnitr Lek 2015 Oct;61(10):873-6.PMID:26486480doi
Importance of subclinical thyroid disease (STh) is now a matter of discussion. Definition of this unit is laboratory: in presence of normal level of thyroxine (T4) TSH value is changed: in lower TSH level the subclinical hyperthyroidism (STx) in increase TSH levels subclinical hypothyroidism (SH) is present. Risk of clinical manifestation is two three times highter in comparison with persons with normal TSH level. Clinical importance STh is still not evaluated definitively. SH caused disturbance of lipid metabolism, elasticity of vessels and endothelial function and therefore increases risk of atherosclerosis. STx causes electrical instability of myocardium with increased risk of arythmias, increases risk of osteoporosis and other changes. Most important are effects of STh in cardiology, reproductive medicine and gynecology. Clinical significance of these effects is not definitively evaluated.