SMARCA4 Human
目录号 : GP24617SMARCA4 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 80.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | SWI/SNF Related; Matrix Associated; Actin DependentRegulator Of Chromatin; Subfamily A; Member 4; Mitotic Growth And TranscriptionActivator; ATP-Dependent Helicase SMARCA4; BRG1; Global Transcription ActivatorHomologous Sequence Sucrose Nonfermenting-Like 4; BRG1-Associated Factor 190A;Protein Brahma Homolog 1; BRM/SWI2-Related Gene 1; Homeotic Gene Regulator; BrahmaProtein-Like 1 Nuclear Protein GRB1; Protein BRG-1; SNF2-Like 4; SNF2-Beta;BAF190A; SNF2L4; MRD16; RTPS2; SWI/SNF-Related Matrix-AssociatedActin-Dependent Regulator Of Chromatin Subfamily A Member 4; TranscriptionActivator BRG1; EC 3.6.4.-; EC 3.6.1; BAF190; SNF2LB; HSNF2b; SNF2B; SNF2; SWI2;Transcription activator BRG1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSDPVEILQ EREYRLQARI AHRIQELENL PGSLAGDLRT KATIELKALRLLNFQRQLRQ EVVVCMRRDT ALETALNAKA YKRSKRQSLR EARITEKLEK QQKIEQERKR RQKHQEYLNSILQHAKDFKE YHRSVTGKIQ KLTKAVATYH ANTEREQKKENERIEKERMR RLMAEDEEGY RKLIDQKKDK R. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | SMARCA4 protein solution (1mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. | ||
SMARCA4 belongs to the SWI/SNF family of proteins and is similar to thebrahma protein of Drosophila.Proteins in this family have helicase and ATPase activities and are consideredto regulate transcription ofcertain genes by altering the chromatin structure around those genes. SMARCA4is part of the large ATP-dependent chromatinremodeling complex SNF/SWI, which is essential for transcriptional activation of genes normally repressed by chromatin. Inaddition, SMARCA4 is able to bind BRCA1, as well as regulating the expressionof thetumorigenic protein CD44. Moreover, mutations in SMARCA4 cause rhabdoid tumorpredisposition syndrome type 2.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.