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SFRP4 Human, sf9

目录号 : GP24559

Secreted Frizzled-Related Protein 4 Human Recombinant, sf9

SFRP4  Human, sf9 Chemical Structure

规格 价格 库存 购买数量
1μg
¥840.00
5-10工作日
5μg
¥2,030.00
5-10工作日
50μg
¥16,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

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产品描述

SFRP4 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 337 amino acids (19-346 a.a.) andhaving a molecular mass of 38.9kDa (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa). SFRP4 is expressed with a 9 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

Product Data

Purity Greaterthan 90.0% as determined by SDS-PAGE. Source Sf9, Baculovirus cells.
Phycical Appearance Sterile Filtered colorless solution. Shipping Condition Shipped with Ice Packs.
Synonyms Secreted Frizzled Related Protein 4; SecretedFrizzled-Related Protein 4; Frizzled Protein; Human Endometrium; SFRP-4; FRPHESecreted Frizzled-Related Protein 4; Secreted Frizzled-Related Protein 4;FRP-4; PYL; SFRP4; FRPHE.
Amino Acid Sequence ADPVRGAPCE AVRIPMCRHMPWNITRMPNH LHHSTQENAI LAIEQYEELV DVNCSAVLRF FLCAMYAPIC TLEFLHDPIK PCKSVCQRARDDCEPLMKMY NHSWPESLAC DELPVYDRGV CISPEAIVTD LPEDVKWIDI TPDMMVQERP LDVDCKRLSPDRCKCKKVKP TLATYLSKNY SYVIHAKIKA VQRSGCNEVT TVVDVKEIFK SSSPIPRTQV PLITNSSCQCPHILPHQDVL IMCYEWRSRM MLLENCLVEK WRDQLSKRSI QWEERLQEQR RTVQDKKKTA GRTSRSNPPKPKGKPPAPKP ASPKKNIKTR SAQKRTNPKR VHHHHHH
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Formulation SFRP4 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.

Introduction

Secreted frizzled-related protein 4 (SFRP4) belongs to the SFRP family which contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs serve as soluble modulators of Wnt signaling. SFRP4 may serve as a regulator of adult uterine morphology and function. SFRP4 increases apoptosis during ovulation possibly via modulation of FZ1/FZ4/WNT4 signaling. SFRP4 also has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. SFRP4 is expressed in proliferative endometrium and several types of ovarian, endometrial and Brest tumors. SFRP4 is expressed in mesenchymal cells and in cardiomyocytes. SFRP4 expression in ventricular myocardium correlates with apoptosis related gene expression. SFRP4 is up-regulated in failing myocardium.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.