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SEP15 Human

目录号 : GP24522

15 KDa Selenoprotein Human Recombinant

SEP15 Human Chemical Structure

规格 价格 库存 购买数量
5μg
¥840.00
5-10工作日
20μg
¥2,030.00
5-10工作日
1mg
¥37,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

SEP15 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (29-165 a.a) and having a molecular mass of 17.7kDa.

Product Data

Purity Greater than 95.0% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Sterile Filtered clear solution. Shipping Condition Shipped with Ice Packs.
Synonyms 15 KDa Selenoprotein; SEP15.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSVSAFGAE FSSEACRELG FSSNLLCSSC DLLGQFNLLQ LDPDCRGCCQEEAQFETKKL YAGAILEVCG CKLGRFPQVQ AFVRSDKPKL FRGLQIKYVR GSDPVLKLLD DNGNIAEELSILKWNTDSVE EFLSEKLERI
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Formulation SEP15 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

Introduction

15 KDa Selenoprotein (SEP15) is aprotein-coding gene which contains a selenocysteine (Sec) residue at its activesite. The selenocysteineis encoded by the UGA codon that usually signals translation termination. The3' UTR of selenoproteingenes have a conventional stem-loop structure, the sec insertion sequence(SECIS), which is necessaryfor the recognition of UGA as a Sec codon rather than as a stop signal. Studiesin mouse propose that thisselenoprotein may have redox function and may be implicated in the qualitycontrol of protein folding. This gene is localized on chromosome 1p31, a genetic locus usuallymutated or deleted in human cancers.Diseases associated with SEP15 include lung cancer susceptibility, andchronic lymphocytic leukemia.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.