(S)-Ketoprofen
(Synonyms: (S)-(+)-酮洛芬; (S)-Ketoprofen; Dexketoprofen) 目录号 : GC15977
A potent inhibitor of COX-1 and COX-2
Cas No.:22161-81-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(S)-Ketoprofen, a dual COX1/2 inhibitor, can be used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains. Ketoprofen is photolabile and undergoes degradation when irradiated by sunlight to induce various skin diseases [1].
In vitro: The combination of UVB irradiation with ketoprofen dose-dependently induced the cytotoxicity and suppressed DNA synthesis in HaCaT cells. UVB-irradiated KP inhibited the cell growth and induced G2/M cell cycle arrest by regulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. The DAPI staining results has revealed that KP accentuated the apoptotic response to UVB radiation in HaCaT cells [1].
In vivo: In a placebo-controlled, double-blind study in the rhesus monkeys Macaca mulatta with periodontal disease, administeration of KP at 1% level in suitable topical vehicles to the gingiva once daily at a standard dose of 1.8 ml per monkey for 6 months effectively inhibited GCF-LTB4 and GCF-PGE2 and positively altered alveolar bone activity [2]. Ketoprofen at a dose of 3.63 mg/kg bwt (phenylbutazone equimolar dose) showed significant analgesic effects and reduced hoof pain and lameness to a greater extent [3]. Treatment with Ketoprofen (40 and 80 mg/kg diet) greatly reduced the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice [4].
References:
[1]. Liu S, Mizu H, Yamauchi H. Molecular response to phototoxic stress of UVB-irradiated ketoprofen through arresting cell cycle in G2/M phase and inducing apoptosis[J]. Biochemical and biophysical research communications, 2007, 364(3): 650-655.
[2]. Li K L, Vogel R, Jeffcoat M K, et al. The effect of ketoprofen creams on periodontal disease in rhesus monkeys[J]. Journal of periodontal research, 1996, 31(8): 525-532.
[3]. Owens J G, Kamerling S G, Stanton S R, et al. Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse[J]. Equine Veterinary Journal, 1995, 27(4): 296-300.
[4]. Hawk E T, Kelloff G J, McCormick D L. Differential activity of aspirin, ketoprofen and sulindac as cancer chemopreventive agents in the mouse urinary bladder[J]. Carcinogenesis, 1996, 17(5): 1435-1438.
| Cas No. | 22161-81-5 | SDF | |
| 别名 | (S)-(+)-酮洛芬; (S)-Ketoprofen; Dexketoprofen | ||
| 化学名 | (S)-3-benzoyl-α-methyl-benzeneacetic acid | ||
| Canonical SMILES | O=C(C1=CC=CC([C@H](C)C(O)=O)=C1)C2=CC=CC=C2 | ||
| 分子式 | C16H14O3 | 分子量 | 254.3 |
| 溶解度 | ≥ 10.6mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9324 mL | 19.6618 mL | 39.3236 mL |
| 5 mM | 0.7865 mL | 3.9324 mL | 7.8647 mL |
| 10 mM | 0.3932 mL | 1.9662 mL | 3.9324 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。