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Home >> Signaling Pathways >> Tyrosine Kinase >> PDGFR

PDGFR(血小板衍生生长因子受体)

PDGFR (platelet-derived growth factor receptor) is a group of cell surface tyrosine kinase receptors for members of the PDGF (platelet-derived growth factor) family.

Products for  PDGFR

  1. Cat.No. 产品名称 Information
  2. GC17024 DMPQ dihydrochloride An potent inhibitor of PDGFRβ
  3. GC10314 Imatinib (STI571) 伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用，将其锁定在封闭或自我抑制的构象中，从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。
  4. GC12980 CP-673451 A selective PDGFRα/β kinase inhibitor
  5. GC11003 PP121 A potent dual inhibitor of tyrosine and phosphoinositide kinases
  6. GC17651 Sunitinib Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶抑制剂，对 VEGFR2 和 PDGFRβ 的 IC50 分别为 80 nM 和 2 nM。 Sunitinib 是一种 ATP 竞争性抑制剂，通过抑制自身磷酸化和随后的 RNase 激活，有效抑制 Ire1α 的自身磷酸化。
  7. GC15254 Tandutinib (MLN518) An antagonist of PDGFRβ, FLT3, and c-Kit
  8. GC10220 TAK-593 TAK-593 是一种有效的 VEGFR 和 PDGFR 家族抑制剂，对 VEGFR1、VEGFR2、VEGFR3、PDFGRα 和 PDFGRβ 的 IC50 分别为 3.2、0.95、1.1、4.3 和 13 nM。
  9. GC13914 Flumatinib mesylate A Bcr-Abl inhibitor
  10. GC11763 Telatinib (BAY 57-9352) A multi-kinase inhibitor
  11. GC15739 CHIR-124 A selective Chk1 inhibitor
  12. GC16337 MK-2461 A c-MET inhibitor
  13. GC12216 Axitinib (AG 013736) A VEGFR inhibitor
  14. GC12730 Pazopanib Hydrochloride A multi-kinase inhibitor
  15. GC14906 Crenolanib (CP-868596) An inhibitor of PDGFRα/β and FLT3
  16. GC13045 Tyrphostin AG 1296 An inhibitor of PDGF receptor kinase
  17. GC14396 Ponatinib (AP24534) An inhibitor of native and mutant Bcr-Abl
  18. GC16732 TSU-68 (SU6668,Orantinib) An inhibitor of select receptor tyrosine kinases
  19. GC15454 Lenvatinib (E7080)

    An inhibitor of VEGFR2 and VEGFR3
  20. GC16421 Cediranib (AZD217) An inhibitor of VEGF receptor tyrosine kinases
  21. GC13547 Dovitinib (TKI-258, CHIR-258) A multi-kinase inhibitor
  22. GC11759 Imatinib Mesylate (STI571) An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit
  23. GC17958 Linifanib (ABT-869) A dual VEGFR and PDGFR family kinase inhibitor
  24. GC13410 Masitinib (AB1010) An inhibitor of c-Kit
  25. GC14683 Sunitinib malate A multi-kinase inhibitor
  26. GC11705 Nintedanib (BIBF 1120) A VEGFR, FGFR, and PDGFR inhibitor
  27. GC16499 Sorafenib Tosylate A multi-kinase inhibitor
  28. GC12776 SKLB610 An inhibitor of VEGFR2
  29. GC10111 Regorafenib A multi-kinase inhibitor
  30. GC12656 ZM323881 A potent and selective VEGFR2 inhibitor
  31. GC10719 Toceranib A multi-targeted receptor tyrosine kinase inhibitor
  32. GC11622 TG 100801 TG 100801 是一种前药，可通过在开发过程中的去酯化作用产生 TG 100572，以治疗年龄相关性黄斑变性。 TG 100572 是一种多靶点激酶抑制剂，可抑制受体酪氨酸激酶和 Src 激酶；对于 VEGFR1、VEGFR2、FGFR1、FGFR2、PDGFRβ、Fgr、Fyn、Hck、Lck、Lyn、Src、Yes ， 分别。
  33. GC14315 SU14813 maleate A dual VEGFR and PDGFR family kinase inhibitor
  34. GC14733 SU14813 A dual VEGFR and PDGFR family kinase inhibitor
  35. GC14660 SU 5402 An inhibitor of VEGFR2, FGFR1, and PDGFRβ
  36. GC14534 Regorafenib monohydrate A multi-kinase inhibitor
  37. GC14606 Regorafenib hydrochloride A multi-kinase inhibitor
  38. GC13264 Ki20227 A c-Fms kinase inhibitor
  39. GC15263 Imatinib hydrochloride V-Abl/c-Kit/PDGFR inhibitor
  40. GC11171 DCC-2618 A dual inhibitor of c-Kit and c-MET
  41. GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor
  42. GC16519 ENMD-2076 A multi-kinase inhibitor
  43. GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid 是一种多靶点激酶抑制剂，对 Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1 的 IC50 为 1.86、14、58.2、15.9、92.7、70.8、56.4 nM , FGFR2, Src, PDGFRα, 分别。
  44. GC16327 Pazopanib (GW-786034) A multi-kinase inhibitor
  45. GC17369 Sorafenib

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.
  46. GN10603 Sennoside B A glycoside with laxative and gastroprotective activities

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