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MGMT(O-6-甲基鸟嘌呤-DNA甲基转移酶)

MGMT (O-6-methylguanine-DNA methyltransferase) is an enzyme that repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription.

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  2. GC13745 O6-Benzylguanine O6-Benzylguanine 是一种鸟嘌呤类似物,是 DNA 修复酶 O6-烷基鸟嘌呤-DNA 烷基转移酶 (MGMT/AGT) 抑制剂。 O6-苄基鸟嘌呤作为 AGT 底物,将其苄基转移到 AGT 半胱氨酸残基上,从而不可逆地使 AGT 失活并阻止 DNA 修复。 O6-Benzylguanine 诱导肿瘤细胞凋亡。抗肿瘤活性。

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