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Hexokinases phosphorylates glucose to generate glucose-6-phosphate, the initial step in glucose metabolism. HK1 and HK2 are two subtypes of mitochondrial hexokinases whichs are also involved in antiapopotic and cell survival.

  1. Cat.No. 产品名称 Information
  2. GC17430 2-Deoxy-D-glucose

    2-Deoxy-D-glucose (2DG), is a glucose analogue, act as competitive glycolytic inhibitor.

  3. GC15523 3-Bromopyruvic acid 3-Bromopyruvate (Bromopyruvic acid) 是丙酮酸的类似物,是一种有效的己糖激酶 (HK)-II 抑制剂,具有高肿瘤选择性。 3-Bromopyruvate 通过干扰糖酵解抑制细胞生长并诱导细胞凋亡。 3-Bromopyruvate 通过刺激乳腺癌细胞中的 ROS 形成来诱导自噬。抗菌活性。
  4. GC11532 Lonidamine Lonidamine (AF-1890) 是一种己糖激酶和线粒体丙酮酸载体抑制剂(Ki:2.5 μM)。

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