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3-Bromopyruvic acid Sale

(Synonyms: 3-溴丙酮酸; Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP) 目录号 : GC15523

An alkylating agent and antimetabolite of pyruvate

3-Bromopyruvic acid Chemical Structure

Cas No.:1113-59-3

规格 价格 库存 购买数量
1g
¥378.00
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5g
¥420.00
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10g
¥557.00
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25g
¥1,176.00
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产品描述

3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells.Target: hexokinase II in vitro: 3-BrPA dissociates HK II from this complex, causing cell death, and thus, having an anti-tumor effect. In vitro treatment of cells with 3-BrPA significantly inhibited their growth, as evaluated by MTT assay and adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA). [1] 3-Bromopyruvic acid (3-BP) is a glycolytic inhibitor and a promising anticancer compound, induces oxidative stress and depletes cells of glutathione (GSH). [2]in vivo: 3-BrPA treatment (50 mg/kg ip. daily, 6 days/week for three weeks) is effective in the animal model by attenuating tumor growth and causing tumor necrosis. Toxic signs were not observed. The acute toxicity study provided an LD50 of 191.7 mg/kg for 3-BrPA. [1]

References:
[1]. Gong L, et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings. Anticancer Agents Med Chem. 2014 Jun;14(5):771-6.
[2]. Sadowska-Bartosz I, et al. Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione. Pharmacol Rep. 2016 Apr;68(2):502-5.

Chemical Properties

Cas No. 1113-59-3 SDF
别名 3-溴丙酮酸; Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP
化学名 3-bromo-2-oxopropanoic acid
Canonical SMILES BrCC(C(O)=O)=O
分子式 C3H3BrO3 分子量 166.96
溶解度 ≥ 16.7mg/mL in Water 储存条件 Store at 2-8°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 5.9895 mL 29.9473 mL 59.8946 mL
5 mM 1.1979 mL 5.9895 mL 11.9789 mL
10 mM 0.5989 mL 2.9947 mL 5.9895 mL
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