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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

iGluR(离子型谷氨酸受体)

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Products for  iGluR

  1. Cat.No. 产品名称 Information
  2. GC19346 Talampanel

    (8R)-7-乙酰基-5-(4-氨基苯基)-8,9-二氢-8-甲基-7H-1,3-二氧杂环戊烯并[4,5-H][2,3]苯并二氮杂卓,GYKI-53773; LY-300164

     An allosteric AMPA receptor antagonist
  3. GC19310 Ro 25-6981 A potent, NR2B-selective NMDA receptor antagonist
  4. GC18410 Ro 25-6981 (maleate) A potent, NR2B-selective NMDA receptor antagonist
  5. GC18223 Farampator

    CX-691; Org24448

     A positive allosteric modulator of AMPA receptors
  6. GC11124 Lanicemine

    拉尼西明; AZD6765

     A low-trapping NMDA channel blocker
  7. GC16562 PEAQX

    NVP-AAM077

     PEAQX是一种强效且有口服活性的NMDA受体拮抗剂，对hNMDA 1A/2A和1A/2B受体的IC50值分别为0.270μM和29.6μM。
  8. GC16315 D-AP5

    (R)-(-)-2-氨基-5-膦酰戊酸,D-2-Amino-5-Phosphonovaleric acid; D-APV

     D-AP5是一种选择性N-甲基-D-天门冬胺酸（NMDA）受体拮抗剂，Kd 值为1.4μM。
  9. GC12703 Philanthotoxin 74

    PhTx 74 dihydrochloride

     An AMPA receptor antagonist
  10. GC16776 QNZ 46 An antagonist of NR2C- and NR2D-subunit containing NMDA receptors
  11. GC13290 CMPDA A positive allosteric modulator of GluA2
  12. GC13684 S 18986 A positive allosteric modulator of AMPA receptors
  13. GC13007 PEPA A positive allosteric modulator of AMPA receptors
  14. GC14414 CIQ

    (3-氯苯基)[3,4-二氢-6,7-二甲氧基-1-[(4-甲氧基苯氧基)甲基]-2(1H)-异喹啉基]甲酮

     A subunit-selective NMDA receptor potentiator
  15. GC11395 7-Chlorokynurenic acid sodium salt

    7-氯犬尿喹啉酸钠盐,7-CKA sodium salt

     A glycine-site selective NMDA receptor antagonist
  16. GC14495 CX 546

    苯并二氧六环-6-(1-哌啶基)甲酰胺

     CX 546是一种强效的3-羟基-5-甲基-4-异唑丙酸（AMPA）受体激活剂，EC50值为93.2µM。
  17. GC14842 GYKI 53655 hydrochloride

    LY300168 hydrochloride

     GYKI 53655 (LY300168) hydrochloride 是一种 α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) 拮抗剂。
  18. GC16300 ZK 200775

    ZK200775; MPQX

     ZK 200775 (ZK200775) 是一种高度选择性的 AMPA/红藻氨酸拮抗剂，对 NMDA 几乎没有活性； Ki 值分别为 3.2 nM、100 nM 和 8.5 μ；M 分别针对 quisqualate、红藻氨酸和 NMDA。
  19. GC15343 Eliprodil

    依利罗地,SL-820715

     An NMDA receptor antagonist
  20. GC18079 CFM-2 CFM-2 是一种有效且选择性的非竞争性 AMPAR 拮抗剂。
  21. GC12863 1-BCP

    Piperonylic acid piperidide

     A positive allosteric modulator of AMPA receptors
  22. GC13728 SYM 2206

    8-(4-氨基苯基)-5-甲基-N-丙基-1,3-二氧杂环戊烯并[4,5-G]酞嗪-6(5H)-甲酰胺

     SYM 2206 是一种有效的非竞争性 AMPA 受体拮抗剂，IC50 为 1.6 μM。
  23. GC14810 L-701,324

    7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉

     An NMDA receptor antagonist
  24. GC16101 SYM 2081

    (2S,4R)-4-甲基谷氨酸

     SYM 2081 是一种高亲和力配体和有效的红藻氨酸受体激动剂，抑制 [3H]-红藻氨酸结合，IC50 为 35 nM，对红藻氨酸受体的选择性分别是 AMPA 和 NMDA 受体的近 3000 倍和 200 倍[1 ]。
  25. GC14156 NBQX

    二羟基喹酮,FG9202

     NBQX是一种高度选择性和竞争性的AMPA受体拮抗剂。
  26. GC11889 (S)-(-)-5-Fluorowillardiine

    5-氟代尿嘧啶丙氨酸; (5S)-Fluorowillardiine; (S)-5-Fluorowillardiine

     (S)-(-)-5-Fluorowillardiine 是一种有效且特异性的 AMPAR 激动剂。
  27. GC10781 7-Chlorokynurenic acid

    7-氯犬尿酸,7-CKA

     A glycine-site selective NMDA receptor antagonist
  28. GC11799 CNQX

    6-氰基-7-硝基喹喔啉-2,3-二酮,FG9065

     CNQX是一种有效的竞争性AMPA /海藻酸酯受体(AMPA/kainate receptor)拮抗剂,IC50 分别为0.3µM和1.5µM。
  29. GC14492 PF 4778574

    PF 4778574 是 AMPA 受体的正向变构调节剂，在不同细胞中的 EC50 为 45 至 919 nM。
  30. GC11585 TCN 237 dihydrochloride TCN 237 dihydrochloride 是一种有效的 NR2B 选择性 NMDA 拮抗剂，Ki 为 0.85 nM； NR2B Ca2+ 内流 IC50 为 9.7 nM；对 NR2A、NR2C、NR2D、hERG 通道和 α1-肾上腺素能受体无活性。
  31. GC14121 GLYX 13

    雷帕替奈; GLYX-13

     A partial agonist of the NMDA receptor
  32. GC13349 Naspm trihydrochloride

    N-[3-[[4-[(3-氨基丙基)氨基]丁基]氨基]丙基]-1-萘乙酰胺三盐酸盐,1-Naphthylacetyl spermine trihydrochloride

     A synthetic analog of Joro spider toxin
  33. GC11715 Ibotenic acid

    鹅膏氨酸,(RS)-Ibotenic acid; DL-Ibotenic acid

     Ibotenic acid是一种神经毒素，对N-甲基-D-天冬氨酸（NMDA）和反式ACPD或代谢使君子酸（Qm）受体位点均具有激动剂活性。
  34. GC14547 Quinolinic acid

    喹啉酸

     An excitotoxic agonist at NMDA receptors
  35. GC18033 γDGG

    Γ-D-谷氨酰基甘氨酸,γDGG; γ-D-Glutamylglycine

     γDGG 是一种竞争性 AMPA 受体阻滞剂。
  36. GC13010 LY451395

    LY451395

     LY451395 (LY451395) 是一种有效且高度选择性的 AMPA 受体增强剂。
  37. GC13779 Orphenadrine Citrate

    枸酸芬那君

     Orphenadrine citrate 是一种具有口服活性且非竞争性的 NMDA 受体拮抗剂（穿过血脑屏障），Ki 为 6.0 μM。
  38. GC13469 Piracetam

    吡拉西坦; UCB-6215

     An Analytical Reference Standard
  39. GC15363 Felbamate hydrate

    W-554 hydrate; ADD-03055 hydrate

     An inhibitor of NMDA receptors and a modulator of GABAA receptors
  40. GC10522 Felbamate

    非尔氨酯; W-554; ADD-03055

     An inhibitor of NMDA receptors and a modulator of GABAA receptors
  41. GC10443 Meclofenoxate hydrochloride

    盐酸甲氯酚酯

     A nootropic agent
  42. GC16899 Coluracetam

    考拉西坦; MKC-231

     An Analytical Reference Standard
  43. GC11470 Flupirtine maleate

    氟吡啶马来酸

     An activator of Kv7 channels
  44. GC14039 MDL-29951

    An NMDA receptor antagonist and GPR17 agonist
  45. GC16986 SDZ 220-581 hydrochloride

    (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐

     SDZ 220-581 hydrochloride 是一种口服有效的竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。
  46. GC17695 Aniracetam

    茴拉西坦; Ro 13-5057

     An Analytical Reference Standard
  47. GC10198 Memantine hydrochloride

    盐酸美金刚; D-145 hydrochloride

     Memantine hydrochloride是一种非竞争性N-甲基-D-天冬氨酸受体（NMDAR）拮抗剂，IC50值为0.5-1μM。
  48. GC17456 NMDA (N-Methyl-D-aspartic acid)

    N-甲基-D-天冬氨酸; N-Methyl-D-aspartic acid

     An excitatory neurotransmitter
  49. GC18118 SDZ 220-581

    (S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸,SDZ 220 581

     SDZ 220-581 是一种具有口服活性、强效、竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。
  50. GC10270 Noopept

    N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯,GVS-111;GVS111;GVS 111;SGS-111;SGS 111;SGS111

     An Analytical Reference Standard
  51. GC13164 Ampalex

    安帕来斯; BDP 12

     An AMPA receptor modulator

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