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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

iGluR(离子型谷氨酸受体)

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Products for  iGluR

  1. Cat.No. 产品名称 Information
  2. GC12703 Philanthotoxin 74 An AMPA receptor antagonist
  3. GC16776 QNZ 46 An antagonist of NR2C- and NR2D-subunit containing NMDA receptors
  4. GC13290 CMPDA A positive allosteric modulator of GluA2
  5. GC13684 S 18986 A positive allosteric modulator of AMPA receptors
  6. GC13007 PEPA A positive allosteric modulator of AMPA receptors
  7. GC14414 CIQ A subunit-selective NMDA receptor potentiator
  8. GC11395 7-Chlorokynurenic acid sodium salt A glycine-site selective NMDA receptor antagonist
  9. GC14495 CX 546 CX 546 是第一代选择性苯甲酰胺型正 AMPAR 调节剂。
  10. GC14842 GYKI 53655 hydrochloride GYKI 53655 (LY300168) hydrochloride 是一种 α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) 拮抗剂。
  11. GC16300 ZK 200775 ZK 200775 (ZK200775) 是一种高度选择性的 AMPA/红藻氨酸拮抗剂，对 NMDA 几乎没有活性； Ki 值分别为 3.2 nM、100 nM 和 8.5 μ；M 分别针对 quisqualate、红藻氨酸和 NMDA。
  12. GC15343 Eliprodil An NMDA receptor antagonist
  13. GC18079 CFM-2 CFM-2 是一种有效且选择性的非竞争性 AMPAR 拮抗剂。
  14. GC12863 1-BCP A positive allosteric modulator of AMPA receptors
  15. GC13728 SYM 2206 SYM 2206 是一种有效的非竞争性 AMPA 受体拮抗剂，IC50 为 1.6 μM。
  16. GC14810 L-701,324 An NMDA receptor antagonist
  17. GC16101 SYM 2081 SYM 2081 是一种高亲和力配体和有效的红藻氨酸受体激动剂，抑制 [3H]-红藻氨酸结合，IC50 为 35 nM，对红藻氨酸受体的选择性分别是 AMPA 和 NMDA 受体的近 3000 倍和 200 倍[1 ]。
  18. GC14156 NBQX

    NBQX is a highly selective and competitive AMPA receptor antagonist.
  19. GC11889 (S)-(-)-5-Fluorowillardiine (S)-(-)-5-Fluorowillardiine 是一种有效且特异性的 AMPAR 激动剂。
  20. GC10781 7-Chlorokynurenic acid A glycine-site selective NMDA receptor antagonist
  21. GC11799 CNQX CNQX是一种有效的竞争性AMPA /海藻酸酯受体(AMPA/kainate receptor)拮抗剂,IC50 分别为0.3µM和1.5µM。.
  22. GC14492 PF 4778574 PF 4778574 是 AMPA 受体的正向变构调节剂，在不同细胞中的 EC50 为 45 至 919 nM。
  23. GC11585 TCN 237 dihydrochloride TCN 237 dihydrochloride 是一种有效的 NR2B 选择性 NMDA 拮抗剂，Ki 为 0.85 nM； NR2B Ca2+ 内流 IC50 为 9.7 nM；对 NR2A、NR2C、NR2D、hERG 通道和 α1-肾上腺素能受体无活性。
  24. GC14121 GLYX 13 A partial agonist of the NMDA receptor
  25. GC13349 Naspm trihydrochloride A synthetic analog of Joro spider toxin
  26. GC11715 Ibotenic acid An excitotoxic NMDA and metabotropic glutamate receptor agonist
  27. GC14547 Quinolinic acid An excitotoxic agonist at NMDA receptors
  28. GC18033 γDGG γDGG 是一种竞争性 AMPA 受体阻滞剂。
  29. GC13010 LY451395 LY451395 (LY451395) 是一种有效且高度选择性的 AMPA 受体增强剂。
  30. GC13779 Orphenadrine Citrate Orphenadrine citrate 是一种具有口服活性且非竞争性的 NMDA 受体拮抗剂（穿过血脑屏障），Ki 为 6.0 μM。
  31. GC13469 Piracetam An Analytical Reference Standard
  32. GC15363 Felbamate hydrate An inhibitor of NMDA receptors and a modulator of GABAA receptors
  33. GC10522 Felbamate An inhibitor of NMDA receptors and a modulator of GABAA receptors
  34. GC10443 Meclofenoxate hydrochloride A nootropic agent
  35. GC16899 Coluracetam An Analytical Reference Standard
  36. GC11470 Flupirtine maleate An activator of Kv7 channels
  37. GC14039 MDL-29951 An NMDA receptor antagonist and GPR17 agonist
  38. GC16986 SDZ 220-581 hydrochloride SDZ 220-581 hydrochloride 是一种口服有效的竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。
  39. GC17695 Aniracetam An Analytical Reference Standard
  40. GC10198 Memantine hydrochloride An NMDA receptor antagonist
  41. GC17456 NMDA (N-Methyl-D-aspartic acid) An excitatory neurotransmitter
  42. GC18118 SDZ 220-581 SDZ 220-581 是一种具有口服活性、强效、竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。
  43. GC10270 Noopept An Analytical Reference Standard
  44. GC13164 Ampalex An AMPA receptor modulator
  45. GC16149 Topiramate An anticonvulsant
  46. GN10122 Linalool A monoterpene alcohol with diverse biological activities
  47. GA11306 H-D-Ser-OH An NMDA co-agonist
  48. GA10922 H-Gly-OH H-Gly-OH 是 CNS 中的一种抑制性神经递质，还与谷氨酸一起作为共激动剂，促进谷氨酰胺能 N-甲基-D-天冬氨酸 (NMDA) 受体的兴奋电位。
  49. GA10750 H-Glu-OH H-Glu-OH 在谷氨酸受体的所有亚型（代谢型、红藻氨酸、NMDA 和 AMPA）中充当兴奋性递质和激动剂。
  50. GA11338 H-D-Asp-OH An amino acid and a precursor in NMDA biosynthesis

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