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7-Chlorokynurenic acid Sale

(Synonyms: 7-氯犬尿酸,7-CKA) 目录号 : GC10781

A glycine-site selective NMDA receptor antagonist

7-Chlorokynurenic acid Chemical Structure

Cas No.:18000-24-3

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥842.00
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10mg
¥765.00
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50mg
¥3,060.00
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100mg
¥5,580.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

7-Chloro-4-hydroxyquinoline-2-carboxylic acid (7-Chlorokynurenic acid) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chloro-4-hydroxyquinoline-2-carboxylic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chloro-4-hydroxyquinoline-2-carboxylic acid has potent antinociceptive actions after neuraxial delivery[1][2].

Male Sprague-Dawley rats pretreated with 7-Chloro-4-hydroxyquinoline-2-carboxylic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3].

References:
[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.
[2]. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196.
[3]. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.

Chemical Properties

Cas No. 18000-24-3 SDF
别名 7-氯犬尿酸,7-CKA
化学名 7-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Canonical SMILES ClC1=CC=C2C(NC(C(O)=O)=CC2=O)=C1
分子式 C10H6ClNO3 分子量 223.62
溶解度 DMSO: slightly soluble,Ethanol: slightly soluble 储存条件 Store at RT
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1 mM 4.4719 mL 22.3594 mL 44.7187 mL
5 mM 0.8944 mL 4.4719 mL 8.9437 mL
10 mM 0.4472 mL 2.2359 mL 4.4719 mL
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