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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Cyclin-Dependent Kinases

Cyclin-Dependent Kinases(细胞周期蛋白依赖性激酶)

Cyclin-dependent kinases is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.

Products for  Cyclin-Dependent Kinases

  1. Cat.No. 产品名称 Information
  2. GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
  3. GC15841 Alsterpaullone A dual CDK and GSK3 inhibitor
  4. GC16520 Olomoucine An inhibitor of cyclin-dependent kinases
  5. GC15215 Iso-Olomoucine An inactive stereoisomer of olomoucine
  6. GC14294 Cdk1/2 Inhibitor III A cell-permeable inhibitor of Cdk1 and Cdk2
  7. GC11564 Cdk4/6 Inhibitor IV A cell-permeable inhibitor of Cdk4/6
  8. GC15607 ON123300 A multi-kinase inhibitor
  9. GC14002 Bohemine A Cdk inhibitor
  10. GC15173 PD 0332991 (Palbociclib) PD 0332991 (Palbociclib) (PD 0332991) 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 PD 0332991 (Palbociclib) 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
  11. GC18051 CCT251545 analogue, Compound 51

    Potent, Selective, orally bioavailable CDK 8/19 Inhibitor
  12. GC16420 THZ531 An inhibitor of Cdk12 and Cdk13
  13. GC14230 K03861 K03861 (K03861) 是一种 II 型 CDK2 抑制剂，Kd 为 8.2 nM。 K03861 (K03861) 通过与活化细胞周期蛋白的结合竞争抑制 CDK2 活性。
  14. GC16545 GX-674 GX-674 是一种有效的、状态依赖性、异构体选择性电压门控钠通道 1.7 (Nav1.7) 拮抗剂，在 -40 mV 时的 IC50 为 0.1 nM。
  15. GC13511 THZ2 A Cdk7 inhibitor
  16. GC12826 AZD-5597

    Potent CDK inhibitor
  17. GC14707 Purvalanol A A selective inhibitor of cyclin-dependent kinases
  18. GC12348 Ro 3306 An inhibitor of Cdk1
  19. GC11971 LY2857785 A Cdk9 inhibitor
  20. GC17067 LDC000067 A Cdk9 inhibitor
  21. GC11944 PF 4800567 hydrochloride A selective CK1ε inhibitor
  22. GC16413 TMCB A dual inhibitor of CK2 and ERK8
  23. GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
  24. GC17150 Ryuvidine An inhibitor of SETD8
  25. GC12886 NSC 625987 A Cdk4/cyclin D1 complex inhibitor
  26. GC11410 Aminopurvalanol A A selective CDK inhibitor
  27. GC11634 NSC 693868 A selective inhibitor of Cdk1 and Cdk5
  28. GC13100 [Ala92]-p16 (84-103) inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1
  29. GC13649 Arcyriaflavin A A CDK4 and CAMKII inhibitor
  30. GC14182 Kenpaullone A inhibitor of cyclin-dependent kinase and GSK3β
  31. GC12642 THZ1 Hydrochloride A covalent Cdk7 inhibitor
  32. GC14162 ML167 A selective Clk4 inhibitor
  33. GC10840 THZ1 A covalent Cdk7 inhibitor
  34. GC15377 LEE011 succinate A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
  35. GC15922 LEE011 hydrochloride A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
  36. GC11785 CDK4 inhibitor An antiproliferative cyclin D1/Cdk4 inhibitor
  37. GC14974 AMG 925 A dual inhibitor of FLT3 and Cdk4
  38. GC16000 WHI-P180 A multi-kinase inhibitor
  39. GC17400 R547 A selective Cdk inhibitor
  40. GC10842 LEE011 A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
  41. GC16425 Flavopiridol hydrochloride An inhibitor of cyclin-dependent kinases
  42. GC11835 Deferasirox An iron chelator with anticancer activity
  43. GC16268 Purvalanol B A CDK inhibitor
  44. GC17648 Dinaciclib(SCH727965) A CDK inhibitor
  45. GC12865 BMS265246 A cell-permeable inhibitor of Cdk1 and Cdk2
  46. GC15588 PHA-848125 An inhibitor of Cdks
  47. GC15421 Palbociclib (PD0332991) Isethionate Palbociclib (PD 0332991) isethionate 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 Palbociclib (PD0332991) Isethionate 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
  48. GC12438 AZD-5438 A potent inhibitor of CDKs
  49. GC17935 PD 0332991 (Palbociclib) HCl A selective cyclin D kinase 4/6 inhibitor
  50. GC16822 LY2835219 A dual inhibitor of CDK4 and CDK6
  51. GC15963 Nu 6027 A CDK and ATR inhibitor

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