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Survivin is the smallest member of the inhibitor of apoptosis (IAP) protein family, a family of highly conserved cell apoptosis inhibitors characterized by the presence of a zinc-binding fold (the baculoviral IAP repeat), that is comprised of a single N-terminal BIR domain, a long C-terminal α-helix coiled region and a dimeric arrangement. Survivin is a bifunctional protein, apart from its ability to inhibit apoptosis, which also plays an essential role in proper cell division. Survivin is not expressed in most normal and terminally differentiated adult tissues but expressed in fetal tissues, where its expression is cell cycle-regulated and peaks at mitosis.

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  2. GC60229 LQZ-7I LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。
  3. GC35758 Cucurbitacin IIa Cucurbitacin IIa 是从园果雪胆中分离得到的三萜烯,可诱导癌细胞凋亡。Cucurbitacin IIa 可降低癌细胞中生存素 survivin 的表达,降低磷酸化组蛋白 H3 的水平,增加裂解的 PARP 的水平。
  4. GC33097 GDP366 GDP366是survivin和Op18的双重抑制剂,抑制癌细胞生长,诱导细胞衰老和有丝分裂突变。
  5. GC15632 YM-155 hydrochloride YM-155 hydrochloride (YM-155 hydrochloride) 是一种新型 survivin 抑制剂,抑制 survivin 启动子活性的 IC50 为 0.54 nM。
  6. GC13107 YM155 YM155 (YM-155) 是一种存活素抑制剂,IC50 为 0.54 nM。

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