p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- Cat.No. 产品名称 Information
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GC67765
p53 Activator 5
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GC65961
P53R3
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GC65880
ADH-6 TFA
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GC65284
SLMP53-1
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GC64768
PK9327
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GC64649
Cjoc42
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GC62716
MD-222
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GC62629
MB710
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GC62621
Milademetan tosylate hydrate
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GC62598
MI-1061 TFA
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GC62557
MDM2-IN-1
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GC62322
MS7972
MS7972 is a small molecule that blocks human p53 and CREB binding protein association.
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GC61804
Amifostine thiol
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GC61608
HLI373 dihydrochloride
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GC48652
Olomoucine II
A CDK inhibitor
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GC47853
Paclitaxel-d5
An internal standard for the quantification of paclitaxel
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GC47187
Deoxycholic Acid-d4
An internal standard for the quantification of deoxycholic acid
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GC61352
Triglycidyl isocyanurate
Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
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GC38812
MD-224
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GC45758
Paclitaxel octadecanedioate
A prodrug form of paclitaxel
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GC37761
Tenovin-6 Hydrochloride
A small molecule activator of p53
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GC37549
RO-5963
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GC37013
PROTAC MDM2 Degrader-4
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GC37012
PROTAC MDM2 Degrader-3
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GC37011
PROTAC MDM2 Degrader-2
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GC37010
PROTAC MDM2 Degrader-1
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GC36896
PhiKan 083 hydrochloride
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GC36837
p53 and MDM2 proteins-interaction-inhibitor racemic
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GC36836
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
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GC36835
p53 and MDM2 proteins-interaction-inhibitor chiral
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GC36785
NVP-CGM097 sulfate
An inhibitor of the MDM2-p53 interaction
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GC36605
MI-1061
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GC35511
BI-0252
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GC35367
APG-115
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GC44652
PK7242 (maleate)
An inducer of reactivation of mutant p53
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GC43408
Deoxycholic Acid (sodium salt hydrate)
A secondary bile acid
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GC43297
Coenzyme Q2
A biosynthetic precursor to CoQ10 and an inhibitor of mitochondrial complex I
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GC43239
Chk2 Inhibitor
A Chk2 inhibitor
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GC43190
CAY10682
A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
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GC43189
CAY10681
A dual modulator of p53-MDM2 interaction and NF-κB signaling
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GC42785
Amifostine (hydrate)
A broad-spectrum radioprotective thiol
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GC42586
6α-hydroxy Paclitaxel
A metabolite of paclitaxel
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GC41643
9(Z),11(E),13(E)-Octadecatrienoic Acid
A polyunsaturated fatty acid
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GC40785
9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester
A polyunsaturated fatty acid ethyl ester
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GC40710
9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester
A polyunsaturated fatty acid methyl ester
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GC33384
DPBQ
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GC33356
AM-8735
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GC32946
PK11007
PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
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GC32919
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride)
An activator of p53
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GC32911
CTX1