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The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

  1. Cat.No. 产品名称 Information
  2. GC67765 p53 Activator 5
  3. GC65961 P53R3
  4. GC65880 ADH-6 TFA
  5. GC65284 SLMP53-1
  6. GC64768 PK9327
  7. GC64649 Cjoc42
  8. GC62716 MD-222
  9. GC62629 MB710
  10. GC62621 Milademetan tosylate hydrate
  11. GC62598 MI-1061 TFA
  12. GC62557 MDM2-IN-1
  13. GC62322 MS7972 MS7972 is a small molecule that blocks human p53 and CREB binding protein association.
  14. GC61804 Amifostine thiol
  15. GC61608 HLI373 dihydrochloride
  16. GC48652 Olomoucine II A CDK inhibitor
  17. GC47853 Paclitaxel-d5 An internal standard for the quantification of paclitaxel
  18. GC47187 Deoxycholic Acid-d4 An internal standard for the quantification of deoxycholic acid
  19. GC61352 Triglycidyl isocyanurate Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
  20. GC38812 MD-224
  21. GC45758 Paclitaxel octadecanedioate A prodrug form of paclitaxel
  22. GC37761 Tenovin-6 Hydrochloride A small molecule activator of p53
  23. GC37549 RO-5963
  24. GC37013 PROTAC MDM2 Degrader-4
  25. GC37012 PROTAC MDM2 Degrader-3
  26. GC37011 PROTAC MDM2 Degrader-2
  27. GC37010 PROTAC MDM2 Degrader-1
  28. GC36896 PhiKan 083 hydrochloride
  29. GC36837 p53 and MDM2 proteins-interaction-inhibitor racemic
  30. GC36836 p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
  31. GC36835 p53 and MDM2 proteins-interaction-inhibitor chiral
  32. GC36785 NVP-CGM097 sulfate An inhibitor of the MDM2-p53 interaction
  33. GC36605 MI-1061
  34. GC35511 BI-0252
  35. GC35367 APG-115
  36. GC44652 PK7242 (maleate) An inducer of reactivation of mutant p53
  37. GC43408 Deoxycholic Acid (sodium salt hydrate) A secondary bile acid
  38. GC43297 Coenzyme Q2 A biosynthetic precursor to CoQ10 and an inhibitor of mitochondrial complex I
  39. GC43239 Chk2 Inhibitor A Chk2 inhibitor
  40. GC43190 CAY10682 A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
  41. GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling
  42. GC42785 Amifostine (hydrate) A broad-spectrum radioprotective thiol
  43. GC42586 6α-hydroxy Paclitaxel A metabolite of paclitaxel
  44. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid A polyunsaturated fatty acid
  45. GC40785 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester A polyunsaturated fatty acid ethyl ester
  46. GC40710 9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester A polyunsaturated fatty acid methyl ester
  47. GC33384 DPBQ
  48. GC33356 AM-8735
  49. GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
  50. GC32919 Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) An activator of p53
  51. GC32911 CTX1

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