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p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

Products for  p53

  1. Cat.No. 产品名称 Information
  2. GC33356 AM-8735 AM-8735是有效,选择性的MDM2抑制剂,IC50值为25nM。
  3. GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
  4. GC32919 Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) An activator of p53
  5. GC32911 CTX1

    CTX1是一种新型小分子p53激活剂。

  6. GC32881 Milademetan (DS-3032) Milademetan (DS-3032) (DS-3032) 是一种特异性的、具有口服活性的 MDM2 抑制剂,用于研究急性髓性白血病 (AML) 或实体瘤。 Milademetan (DS-3032) (DS-3032) 诱导 G1 细胞周期停滞、衰老和凋亡。
  7. GC19312 RO8994 An inhibitor of MDM2-p53 interaction
  8. GC19268 NVP-HDM201 NVP-HDM201 (NVP-HDM201) 是一种有效的、口服生物利用度高且高度特异性的 p53-MDM2 相互作用抑制剂。
  9. GC19257 MX69 An inhibitor of the MDM2 protein and XIAP RNA interaction
  10. GC18677 YMU1 A thymidylate kinase inhibitor
  11. GC18624 Roslin-2 A reactivator of p53
  12. GC15613 p-nitro-Cyclic Pifithrin-α A cell-permeable form of cyclic PFT-α
  13. GC15258 GN25 Inhibits p53-Snail binding
  14. GC15225 COTI-2 An activator of mutant forms of p53
  15. GC15812 p-nitro-Pifithrin-α A cell-permeable inactivator of p53
  16. GC15394 CBL0137 (hydrochloride) An activator of p53 and inhibitor of NF-κB
  17. GC14634 CBL0137 An activator of p53 and inhibitor of NF-κB
  18. GC15946 ReACp53 ReACp53 可以抑制 p53 淀粉样蛋白的形成并挽救癌细胞系中的 p53 功能。
  19. GC16151 NSC348884 A nucleophosmin inhibitor
  20. GC18136 BH3I-1 An inhibitor of anti-apoptotic Bcl-2 proteins
  21. GC16179 NSC59984 A p53 reactivator
  22. GC11711 ONC201 A TRAIL-inducing compound
  23. GC11547 MI-773 (SAR405838) An inhibitor of MDM2-p53 protein-protein interactions
  24. GC17262 Pifithrin-β An inactivator of p53
  25. GC11445 YH239-EE A prodrug form of YH 239
  26. GC12647 NVP-CGM097 An inhibitor of the MDM2-p53 interaction
  27. GC16296 MI-773 MI-773 是一种有效的 MDM2-p53 蛋白-蛋白相互作用 (PPI) 抑制剂,对 MDM2 具有高结合亲和力 (Kd=8.2 nM)。 MI-773 具有抗肿瘤活性。
  28. GC14755 Inauhzin A selective SIRT1 inhibitor
  29. GC15828 AMG232 An inhibitor of the MDM2 and p53 interaction
  30. GC12337 Tenovin-3 A small molecule activator of p53
  31. GC16436 Tenovin-6 A small molecule activator of p53
  32. GC12508 Nutlin-3b The less active enantiomer of (–)-nutlin-3
  33. GC11247 PRIMA-1MET A re-activator of the apoptotic function of mutant p53 proteins
  34. GC11065 Pifithrin-μ Inhibitor of p53-mediated apoptosis
  35. GC10896 Cyclic Pifithrin-α hydrobromide A stable inhibitor of p53
  36. GC11557 WR 1065 A radioprotective agent
  37. GC13590 SJ 172550 A small molecule inhibitor of MDMX
  38. GC10589 RETRA hydrochloride Antitumor agent
  39. GC12086 PRIMA-1 A re-activator of the apoptotic function of mutant p53 proteins
  40. GC12658 PhiKan 083 PhiKan 083 是一种咔唑衍生物,可与表面腔结合并稳定 Y220C(一种 p53 突变体),Kd 为 167 μM。 PhiKan 083 可用于癌症研究。
  41. GC15621 NSC 146109 hydrochloride An activator of p53
  42. GC12893 MIRA-1 A mutant p53 reactivator
  43. GC10650 HLI 373 HLI 373 是一种有效的 Hdm2 抑制剂。
  44. GC15840 CP 31398 dihydrochloride A p53 stabilizing agent
  45. GC10315 Plumbagin A natural naphthoquinone
  46. GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities
  47. GC16371 Solasodine An alkaloid with diverse biological activities
  48. GC11594 RG7388 An inhibitor of the MDM2-p53 interaction
  49. GC13019 RG7112 An inhibitor of the MDM2-p53 interaction
  50. GC10470 Nutlin-3a chiral An inhibitor of the p53-Mdm2 interaction
  51. GC12793 RITA (NSC 652287) An inhibitor of the p53-HDM-2 interaction

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