MDM2
The murine double minute 2 (MDM2) is a protein encoded by the mdm2 gene that functions as an E3 ubiquitin ligase to ubiquitinate the p53 tumor suppressor and promotes the proteasomal degradation of p53. Human MDM2 protein is a phosphoprotein of 491 amino acids that inherits the E3 ubiquitin ligase activity from its evolutionarily conserved COOH terminal of RING finger domain (Zinc-binding), a common motif in E3 ligases. Human MDM2 protein mediates monomeric ubiquitination on multiple lysine residues mainly in the COOH terminus of p53 and directly inhibits the transcriptional activity of p53 through binding to the NH2 terminal transactivation domain of p53.
- Cat.No. 产品名称 Information
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GC10022
SP 141
An inhibitor of MDM2
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GC14154
(±)-Nutlin-3
A racemic mixture of (?)-nutlin-3 and (+)-nutlin-3
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GC11547
MI-773 (SAR405838)
An inhibitor of MDM2-p53 protein-protein interactions
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GC17262
Pifithrin-β
An inactivator of p53
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GC11445
YH239-EE
A prodrug form of YH 239
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GC12508
Nutlin-3b
The less active enantiomer of (–)-nutlin-3
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GC11594
RG7388
An inhibitor of the MDM2-p53 interaction
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GC13019
RG7112
An inhibitor of the MDM2-p53 interaction
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GC12793
RITA (NSC 652287)
An inhibitor of the p53-HDM-2 interaction
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GC12117
JNJ-26854165 (Serdemetan)
An antagonist of MDM2 action
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GC13687
NSC 66811
A potent inhibitor of Mdm2-p53 interaction
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GC12701
NSC 207895 (XI-006)
An inhibitor of MDMX