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The c-RET proto-oncogene, which was originally identified as a transforming gene by transfection of T-cell lymphoma DNA into NIH3T3 cells, is a member of the receptor tyrosine kinase (RTK) gene superfamily that encodes a receptor tyrosine kinase involved in the regulation of glial cell line-derived neurotrophic factor (GDNF) signaling. Signaling proteins, such as Grb7/Grb10, PLCγ, Shc/Enigma and Grb2, are recruited by activated c-RET protein through binding to the phosphorylated tyrosine residues in c-RET protein’s COOH-terminal sequence, Y905, Y1015, Y1062 and Y1096 respectively.  Moreover, results of in vivo studies suggest mutations of c-RET have been implicated in tumorigenesis, in which c-RET mRNA and/or protein have been found in tumors of neuroectodermal origin as well as in human neuroblastoma cell lines.

Products for  c-RET

  1. Cat.No. 产品名称 Information
  2. GC13194 RPI-1 A RET kinase inhibitor
  3. GC16362 AD57 (hydrochloride) A polypharmacological cancer therapeutic
  4. GC10111 Regorafenib

    瑞戈非尼; BAY 73-4506

    A multi-kinase inhibitor
  5. GC15307 SU5416

    司马沙尼; SU5416; Semaxanib

    A tyrosine kinase inhibitor

  6. GC14534 Regorafenib monohydrate

    瑞格非尼一水合物,BAY 73-4506 monohydrate

    A multi-kinase inhibitor
  7. GC14606 Regorafenib hydrochloride

    瑞戈非尼盐酸盐; BAY 73-4506 hydrochloride

    A multi-kinase inhibitor
  8. GC16391 Amuvatinib (MP-470, HPK 56)

    N-(1,3-苯并二氧戊环-5-基甲基)-4-苯并呋喃并[3,2-D]嘧啶-4-基-1-哌嗪硫代甲酰胺,MP470,MP 470,HPK56

    A multi-targeted RTK inhibitor
  9. GC15217 Danusertib (PHA-739358)

    达鲁舍替,5-Amido-pyrrolopyrazole 9d

    A pan-Aurora kinase and Abl inhibitor
  10. GC10035 TG101209


    An inhibitor of JAK2, FLT3, RET, and JAK3

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