Home >> Signaling Pathways >> Apoptosis >> c-RET


The c-RET proto-oncogene, which was originally identified as a transforming gene by transfection of T-cell lymphoma DNA into NIH3T3 cells, is a member of the receptor tyrosine kinase (RTK) gene superfamily that encodes a receptor tyrosine kinase involved in the regulation of glial cell line-derived neurotrophic factor (GDNF) signaling. Signaling proteins, such as Grb7/Grb10, PLCγ, Shc/Enigma and Grb2, are recruited by activated c-RET protein through binding to the phosphorylated tyrosine residues in c-RET protein’s COOH-terminal sequence, Y905, Y1015, Y1062 and Y1096 respectively.  Moreover, results of in vivo studies suggest mutations of c-RET have been implicated in tumorigenesis, in which c-RET mRNA and/or protein have been found in tumors of neuroectodermal origin as well as in human neuroblastoma cell lines.

  1. Cat.No. 产品名称 Information
  2. GC13194 RPI-1 A RET kinase inhibitor
  3. GC16362 AD57 (hydrochloride) A polypharmacological cancer therapeutic
  4. GC10111 Regorafenib A multi-kinase inhibitor
  5. GC15307 SU5416

    A tyrosine kinase inhibitor

  6. GC14534 Regorafenib monohydrate A multi-kinase inhibitor
  7. GC14606 Regorafenib hydrochloride A multi-kinase inhibitor
  8. GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor
  9. GC15217 Danusertib (PHA-739358) A pan-Aurora kinase and Abl inhibitor
  10. GC10035 TG101209 An inhibitor of JAK2, FLT3, RET, and JAK3

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