BTK (Bruton's tyrosine kinase) binds PIP3 and phosphorylates phospholipase C, plays a crucial role in B cell maturation as well as mast cell activation.
- Cat.No. 产品名称 Information
- GC67940 BTK inhibitor 10
- GC67857 (R)-Elsubrutinib
- GC64819 Elsubrutinib
- GC64360 BTK inhibitor 18
- GC64120 TAK-020
- GC63896 AS-1763
- GC63846 BIIB091
- GC63797 (S)-Sunvozertinib DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations with IC50 ranging from 0.4 nM to 2.1 nM for mutant EGFR.
- GC63232 Tolebrutinib Tolebrutinib (SAR442168, PRN2246, BTKi'168, BTKi('168)) is an oral, CNS-penetrant, irreversible inhibitor of Bruton's tyrosine kinase (BTK) with IC50s of 0.4 nM and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
- GC63229 TL-895 TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with IC50 and Ki of 1.5 nM and 11.9 nM, respectively.
- GC62614 SJF620 hydrochloride
- GC62515 Pirtobrutinib A BTK inhibitor
- GC62498 BTK inhibitor 17
- GC62255 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively.
- GC60551 Acalabrutinib D4
- GC60197 Ibrutinib deacryloylpiperidine
- GC39194 Ibrutinib D5 An internal standard for the quantification of ibrutinib
- GC38375 Remibrutinib Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.
- GC37672 Spebrutinib besylate
- GC37048 QL47
- GC36861 PCI 29732 A multi-kinase inhibitor
- GC36661 MT-802 MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).
- GC36289 Ibrutinib-biotin
- GC36127 GDC-0834 Racemate
- GC35684 CHMFL-EGFR-202
- GC35683 CHMFL-BTK-01
- GC35563 Btk inhibitor 1 R enantiomer hydrochloride
- GC35562 Btk inhibitor 1 hydrochloride
- GC35561 Btk inhibitor 1 (Rac)-IBT6A (BTK inhibitor 1) is a racemate of IBT6A and an impurity of Ibrutinib, which is a Btk inhibitor (IC50=0.5 nM), and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
- GC34709 PF-06250112
- GC34097 Tirabrutinib hydrochloride (ONO-4059 (hydrochloride)) A BTK inhibitor
- GC34077 Vecabrutinib (SNS-062)
- GC34075 Zanubrutinib (BGB-3111) A potent and covalent BTK inhibitor
- GC34069 (±)-Zanubrutinib ((±)-BGB-3111)
- GC34062 Evobrutinib (M2951) Evobrutinib 作为一种口服、高选择性、共价的布鲁顿氏酪氨酸激酶抑制剂，具有良好的耐受性和有效性。
- GC33821 Tirabrutinib (ONO-4059) A BTK inhibitor
- GC33064 CG-806 (Luxeptinib)
- GC32844 BMS-986195 A covalent BTK inhibitor
- GC32007 Btk inhibitor 2 Btk inhibitor 2 is a BTK inhibitor.
- GC31760 BMS-935177 BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
- GC31713 BMS-986142 A BTK inhibitor
Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.
- GC31339 PRN1008 PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.
- GC30155 PCI-33380
- GC19333 BTK IN-1 A BTK inhibitor
- GC19162 GDC-0853 A BTK inhibitor
- GC15453 ACP-196 A BTK inhibitor
- GC13219 ONO-4059 A derivative of ONO-4059
- GC14857 LFM-A13 A BTK inhibitor
- GC10924 Btk inhibitor 1 R enantiomer Btk 抑制剂 1 R 对映异构体是依鲁替尼的杂质。 Btk 抑制剂 1 R 对映体可用于 Btk 抑制剂 1 R 对映体依鲁替尼二聚体和 Btk 抑制剂 1 R 对映体加合物的合成。 Ibrutinib 是一种选择性、不可逆的 Btk 抑制剂，IC50 为 0.5 nM。
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