BTK(布鲁顿酪氨酸激酶)
BTK (Bruton's tyrosine kinase) binds PIP3 and phosphorylates phospholipase C, plays a crucial role in B cell maturation as well as mast cell activation.
- Cat.No. 产品名称 Information
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GC67940
BTK inhibitor 10
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GC67857
(R)-Elsubrutinib
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GC64819
Elsubrutinib
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GC64360
BTK inhibitor 18
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GC64120
TAK-020
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GC63896
AS-1763
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GC63846
BIIB091
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GC63797
(S)-Sunvozertinib
DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations with IC50 ranging from 0.4 nM to 2.1 nM for mutant EGFR.
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GC63232
Tolebrutinib
Tolebrutinib (SAR442168, PRN2246, BTKi'168, BTKi('168)) is an oral, CNS-penetrant, irreversible inhibitor of Bruton's tyrosine kinase (BTK) with IC50s of 0.4 nM and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
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GC63229
TL-895
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with IC50 and Ki of 1.5 nM and 11.9 nM, respectively.
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GC62614
SJF620 hydrochloride
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GC62515
Pirtobrutinib
A BTK inhibitor
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GC62498
BTK inhibitor 17
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GC62255
N-piperidine Ibrutinib hydrochloride
N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively.
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GC60551
Acalabrutinib D4
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GC60197
Ibrutinib deacryloylpiperidine
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GC39194
Ibrutinib D5
An internal standard for the quantification of ibrutinib
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GC38375
Remibrutinib
Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.
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GC37672
Spebrutinib besylate
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GC37048
QL47
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GC36861
PCI 29732
A multi-kinase inhibitor
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GC36661
MT-802
MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).
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GC36289
Ibrutinib-biotin
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GC36127
GDC-0834 Racemate
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GC35684
CHMFL-EGFR-202
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GC35683
CHMFL-BTK-01
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GC35563
Btk inhibitor 1 R enantiomer hydrochloride
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GC35562
Btk inhibitor 1 hydrochloride
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GC35561
Btk inhibitor 1
(Rac)-IBT6A (BTK inhibitor 1) is a racemate of IBT6A and an impurity of Ibrutinib, which is a Btk inhibitor (IC50=0.5 nM), and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
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GC34709
PF-06250112
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GC34097
Tirabrutinib hydrochloride (ONO-4059 (hydrochloride))
A BTK inhibitor
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GC34077
Vecabrutinib (SNS-062)
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GC34075
Zanubrutinib (BGB-3111)
A potent and covalent BTK inhibitor
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GC34069
(±)-Zanubrutinib ((±)-BGB-3111)
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GC34062
Evobrutinib (M2951)
Evobrutinib 作为一种口服、高选择性、共价的布鲁顿氏酪氨酸激酶抑制剂,具有良好的耐受性和有效性。
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GC33821
Tirabrutinib (ONO-4059)
A BTK inhibitor
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GC33064
CG-806 (Luxeptinib)
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GC32844
BMS-986195
A covalent BTK inhibitor
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GC32007
Btk inhibitor 2
Btk inhibitor 2 is a BTK inhibitor.
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GC31760
BMS-935177
BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
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GC31713
BMS-986142
A BTK inhibitor
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GC31679
ARQ 531
Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.
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GC31339
PRN1008
PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.
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GC30155
PCI-33380
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GC19333
BTK IN-1
A BTK inhibitor
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GC19162
GDC-0853
A BTK inhibitor
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GC15453
ACP-196
A BTK inhibitor
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GC13219
ONO-4059
A derivative of ONO-4059
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GC14857
LFM-A13
A BTK inhibitor
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GC10924
Btk inhibitor 1 R enantiomer
Btk 抑制剂 1 R 对映异构体是依鲁替尼的杂质。 Btk 抑制剂 1 R 对映体可用于 Btk 抑制剂 1 R 对映体依鲁替尼二聚体和 Btk 抑制剂 1 R 对映体加合物的合成。 Ibrutinib 是一种选择性、不可逆的 Btk 抑制剂,IC50 为 0.5 nM。