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PCI 29732 Sale

(Synonyms: 4-氨基-1-环戊基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-D]嘧啶) 目录号 : GC36861

A multi-kinase inhibitor

PCI 29732 Chemical Structure

Cas No.:330786-25-9

规格 价格 库存 购买数量
Free Sample (0.1-0.5 mg) 待询 待询
10mM (in 1mL DMSO)
¥990.00
现货
2mg
¥757.00
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5mg
¥900.00
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10mg
¥1,440.00
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50mg
¥5,040.00
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100mg
¥8,820.00
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200mg 待询 待询
500mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

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产品描述

PCI-29732 is a multi-kinase inhibitor.1 It inhibits the Tec family kinase BTK and the Src family kinases LCK and LYN (Kis = 8.2, 4.6, and 2.5 nM, respectively), as well as the activity of three receptor tyrosine kinases and seven non-receptor tyrosine kinases by greater than 90% in a panel of over 100 kinases at 10 ?M. PCI-29732 inhibits calcium flux in Ramos B cells and phosphorylation of phospholipase C?1 (PLC?1) with IC50 values of 0.53 and 0.33 ?M, respectively. It is cytotoxic to S1-MI-80, H460/MX20, and KBv200 cancer cells overexpressing the ATP-binding cassette transporter (IC50s = 7.8, 6.3, and 6.02 ?M, respectively).2 PCI-29732 (20 mg/kg), in combination with the DNA topoisomerase I inhibitor topotecan , reduces tumor growth in an H460/MX20 mouse xenograft model.

1.Pan, Z., Scheerens, H., Li, S.J., et al.Discovery of selective irreversible inhibitors for Bruton's tyrosine kinaseChemMedChem2(1)58-61(2007) 2.Ge, C., Wang, F., Ciu, C., et al.PCI29732, a Bruton's tyrosine kinase inhibitor, enhanced the efficacy of conventional chemotherapeutic agents in ABCG2-overexpressing cancer cellsCell. Physiol. Biochem.48(6)2302-2317(2018)

Chemical Properties

Cas No. 330786-25-9 SDF
别名 4-氨基-1-环戊基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-D]嘧啶
Canonical SMILES NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2C5CCCC5
分子式 C22H21N5O 分子量 371.44
溶解度 DMSO: ≥ 53 mg/mL (142.69 mM); Ethanol: 10 mg/mL (26.92 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6922 mL 13.4611 mL 26.9222 mL
5 mM 0.5384 mL 2.6922 mL 5.3844 mL
10 mM 0.2692 mL 1.3461 mL 2.6922 mL
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