Bombesin
(Synonyms: 蛙皮素) 目录号 : GC14014
Bombesin是一种14氨基酸肽，属于蛙皮素相关肽家族，在胃泌素释放和G蛋白受体活化中起重要作用。
Cas No.:31362-50-2
Sample solution is provided at 25 µL, 10mM.
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Bombesin is a 14-amino acid peptide that belongs to the Bombesin-related peptide family and plays an important role in gastrin release and G protein receptor activation[1, 2]. Bombesin, with a carboxyl terminus ending in Gly-His-Leu-Met-NH2, was originally isolated from the skin of the European bell toad (Bombina bombina). Its homologous peptides (such as gastrin-releasing peptide (GRP) and neuromedin B (NMB)) were later found in mammals[3]. Bombesin is a multifunctional neuropeptide that can stimulate gastric and pancreatic secretion, gastrointestinal hormone release, gallbladder contraction, and bronchial contraction[4]. Bombesin is present in amphibian gastric endocrine cells, avian glandular stomach endocrine cells, and avian brain. In mammals, Bombesin is mainly present in nerve cells and fibers[5]. Bombesin can stimulate nuclear factor κB activation and the expression of proangiogenic factors in prostate cancer cells[6].
References:
[1] Vigna S R, Thorndyke M C. Bombesin[M]//The comparative physiology of regulatory peptides. Dordrecht: Springer Netherlands, 1989: 34-60.
[2] LaPelusa A, Jan A. Biochemistry, bombesin[J]. 2019.
[3] Tian Z. QUB-1073: A Bioactice Peptide from the Skin Secretion of Phyllomedusa Rohdei[D]. Queen's University Belfast. Faculty of Medicine, Health and Life Sciences, December, 2018.
[4] Cho W K. Role of the neuropeptide, bombesin, in bile secretion[J]. The Yale Journal of Biology and Medicine, 1997, 70(4): 409.
[5] Chejfec G, Lee I, Warren W H, et al. Bombesin in human neuroendocrine (NE) neoplasms[J]. Peptides, 1985, 6: 107-112.
[6] Levine L, Lucci III J A, Pazdrak B, et al. Bombesin stimulates nuclear factor κB activation and expression of proangiogenic factors in prostate cancer cells[J]. Cancer research, 2003, 63(13): 3495-3502.
Bombesin是一种14氨基酸肽，属于蛙皮素相关肽家族，在胃泌素释放和G蛋白受体活化中起重要作用[1, 2]。Bombesin的羧基末端以Gly-His-Leu-Met-NH2结尾，最初从欧洲铃蟾（Bombina bombina）皮肤中分离，后在哺乳动物中发现其同源肽（例如胃泌素释放肽（GRP）和神经介素B（NMB））[3]。Bombesin是一种多功能神经肽，能够刺激胃液和胰腺分泌、胃肠激素释放、胆囊收缩和支气管收缩[4]。Bombesin存在于两栖动物胃内分泌细胞、鸟类腺胃内分泌细胞和鸟类脑中，在哺乳动物中，Bombesin主要存在于神经细胞和纤维中[5]。Bombesin能够刺激前列腺癌细胞中核因子κB激活和促血管生成因子的表达[6]。
| Cas No. | 31362-50-2 | SDF | |
| 别名 | 蛙皮素 | ||
| 化学名 | (S,Z)-N'1-((5S,6Z,8S,9Z,11S,12Z,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,33Z,35S,36Z,38S)-11-((1H-imidazol-5-yl)methyl)-23-((1H-indol-3-yl)methyl)-43-amino-7,10,13,16,19,22,25,28,31,34,37-undecahydroxy-5-(hydroxy(imino)methyl)-29-(2-hydroxy-2-iminoethy | ||
| Canonical SMILES | CC(C[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCC(O)=N1)([H])CCC(O)=N)([H])CCCNC(N)=N)([H])/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=N)([H])CCSC)([H])CC(C | ||
| 分子式 | C71H110N24O18S | 分子量 | 1619.85 |
| 溶解度 | Soluble to 1 mg/ml in sterile water | 储存条件 | Desiccate at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.6173 mL | 3.0867 mL | 6.1734 mL |
| 5 mM | 0.1235 mL | 0.6173 mL | 1.2347 mL |
| 10 mM | 0.0617 mL | 0.3087 mL | 0.6173 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet