Regaloside C
(Synonyms: 王百合苷 C) 目录号 : GC61236
RegalosideC是从百合属的中分离出来的一种甘油葡糖苷，具有抗炎作用。在H2O2诱导的H9C2细胞中，RegalosideC通过保护线粒体，展现出心肌细胞保护作用。
Cas No.:117591-85-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Regaloside C is a glycerol glucoside isolated from the bulbs of Lilium genus with anti-inflammatory activities. Regaloside C has cardiomyocyte protective activity by protecting the mitochondria in H2O2-induced heart H9C2 cells[1].
[1]. Nhan Nguyen Thi, et al. Phenylpropanoids from Lilium Asiatic hybrid flowers and their anti-inflammatory activities. Applied Biological Chemistry volume 60, pages527-533(2017) [2]. KunchengQiu, et al. Protective effect of total glycosides from lily on H2O2-induced H9C2 cells mitochondrial damage and characterization of the chemical profiles by UHPLC-LTQ-Orbitrap-MSn. Journal of Functional Foods. Volume 71, August 2020, 104036
| Cas No. | 117591-85-2 | SDF | |
| 别名 | 王百合苷 C | ||
| Canonical SMILES | O[C@H](COC(/C=C/C(C=C1)=CC(O)=C1O)=O)CO[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)CO | ||
| 分子式 | C18H24O11 | 分子量 | 416.38 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4017 mL | 12.0083 mL | 24.0165 mL |
| 5 mM | 0.4803 mL | 2.4017 mL | 4.8033 mL |
| 10 mM | 0.2402 mL | 1.2008 mL | 2.4017 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The extraction of phenolic acids and polysaccharides from Lilium lancifolium Thunb. using a deep eutectic solvent
Anal Methods 2021 Mar 18;13(10):1226-1231.PMID:33605948DOI:10.1039/d0ay02352c.
Establishing a fast and effective extraction method for herbs is beneficial for the determination of their main compounds and estimating their quality. In this study, deep eutectic solvents (DESs) were optimized to simultaneously extract three main types of phenolic acids, i.e., regaloside B, Regaloside C, and regaloside E, and polysaccharides from the bulbs of Lilium lancifolium Thunb. Based on the optimized extraction conditions, i.e., an extraction temperature of 50 °C, an extraction time of 40 min, a solid-liquid ratio of 1 : 25, and a ratio of water in the DES of 20%, the extracted amounts of regaloside B, Regaloside C, and regaloside E reached 0.31 ± 0.06 mg g-1, 0.29 ± 0.03 mg g-1, and 3.04 ± 0.38 mg g-1, respectively. The extraction efficiencies were higher than those obtained using conventional organic solvents. Next, the polysaccharide levels were measured and compared with those obtained using a conventional hot water extraction method, and equivalent extraction efficiencies were obtained with the conventional hot water extraction method. This study provides a new application of deep eutectic solvents (DESs) for simultaneously extracting phenolic acids and polysaccharides from the bulbs of L. lancifolium Thunb. Considering the biodegradability and pharmaceutical acceptability, DESs as a class of green solvents could have wide applications in the extraction of natural products.
Analysis of edible characteristics, antioxidant capacities, and phenolic pigment monomers in Lilium bulbs native to China
Food Res Int 2022 Jan;151:110854.PMID:34980390DOI:10.1016/j.foodres.2021.110854.
Lilium is cherished for its health-promoting properties in China. The bulbs of Lilium are rich in phenolic compounds, which are associated with antioxidant capacity. However, no systematic evaluation on phenolic compositions and antioxidant capacities for the edible Lilium native to China has been conducted. Herein, bulbs of 56 wild populations and three cultivars were collected. Their edible characteristics, antioxidant capacities, and pigments have been investigated and analyzed. The results showed that phenolic compounds contributed to the major colors (red, yellow and white) in Lilium bulbs. The seven phenolic pigment monomers responsible for the color of bulbs-cyanidin-3-O-rutinoside, isoquercitrin, regaloside B, Regaloside C, regaloside H, regaloside A and regaloside D-were identified by the combination of HPLC-MS and NMR analysis. The population Lilium regale E. H. Wilson (Maoxian County, Sichuan Province) had the highest antioxidant capacity. According to the quantification results, Lilium bulbs with darker and redder colors possessed larger biomass, better nutrient compositions, significantly higher bioactive constituents, and higher antioxidant capacities than the three currently consumed cultivars of edible lily bulbs. Overall, these findings suggest that the mountainous area of southwest China could be the fourth source of edible lilies with the bulb-colored Lilium species.
Integrative analysis of metabolome and transcriptome provide new insights into the bitter components of Lilium lancifolium and Lilium brownii
J Pharm Biomed Anal 2022 Jun 5;215:114778.PMID:35462288DOI:10.1016/j.jpba.2022.114778.
Lilium, a perennial crop with great ornamental, medicinal and edible value, has been frequently used as functional food and medicine. Lilium lancifolium Thunb. (L. lancifolium) and Lilium brownii F.E.Brown var.viridulum Baker (L. brownii) are the most used medicinal species in China. However, the flavor compounds of these two species have not yet been clear. Here, metabolomics and transcriptome analysis were used to reveal the difference of the bitter substances of L. lancifolium and L. brownii. Qualitative results indicated that nine compounds are commonly existed in L. lancifolium and L. brownii, while nine compounds are unique in L. lancifolium and eight compounds are unique in L. brownii. Furthermore, quantitative results revealed that the content of regaloside A in L. lancifolium was nearly 2-7 folds higher than that of L. brownii, and the content of regaloside B in L. lancifolium was about 4-16 folds higher than that of L. brownii. Regaloside C and E were not detected in L. brownii. Transcriptome analysis showed that there were 90 unique genes up-regulated in L. lancifolium samples in the pathway of phenylpropanoid biosynthesis and 75 unique genes up-regulated in L. brownii samples, which could be related to the different content and chemical structure specificity of phenylpropanoid glycerol glucosides in L. lancifolium and L. brownii. The results of our in-deep research provide new insights into the bitter substances of L. lancifolium and L. brownii, and a further consideration for the chemical consistency and quality evaluation for Lilii bulbus.
[Studies on chemical constituents in fresh fleshy scaleleaf of Lilium lancifolium]
Zhongguo Zhong Yao Za Zhi 2007 Aug;32(16):1656-9.PMID:18027661doi
Objective: To study the chemical constituents in fresh fleshyscaleaf of Lilium lancifolium. Method: The constituents were separated. by various kinds of chromatography and their structures were identified on the basis of spectral analysis. Result: Ten compounds were identified regaloside A (1), Regaloside C (2), methyl-a-D-mannopyranosid (3), methyl-ca-D-glucopyranoside (4), (25R, 26R) -26-methoxyspirost-5-ene-3p-yl-O-ca-L-rhamnopyranosyl-(1-->2)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-glucopyranoside (5), (25R)-spirost-5-ene-3beta-yl-O-alpha-L-rhamnopyranosyl-(1-->2)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-glucopyranoside (6), (25R, 26R)-17alpha-hydroxy-26-methoxyspirost-5-ene-3beta-yl-O-alpha-L-rhamnopyranosyl-(1-->2)-[beta-D-glucopyra nosyl-(1-->6)]-beta-D-glucopyranoside (7), daucosterol (8), adenoside (9), berberine (10). Conclusion: All compounds except 1 and 3 were isolated from this species for the first time, and berberine was first reported in genus Lilium.