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RARRES2 Human, Sf9

目录号 : GP24342

Retinoic Acid Receptor Responder 2 Human Recombinant, Sf9

RARRES2 Human, Sf9 Chemical Structure

规格 价格 库存 购买数量
1μg
¥840.00
5-10工作日
5μg
¥2,030.00
5-10工作日
50μg
¥16,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

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产品描述

RARRES2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 146 amino acids (21-157a.a.) andhaving a molecular mass of 16.9kDa. (Molecular size on SDS-PAGE will appear atapproximately 18-28kDa).RARRES2 is expressed with a6 amino acid His tag at C-Terminus and purified by proprietary chromatographictechniques.

Product Data

Purity Greater than 90.0% as determined by SDS-PAGE. Source Sf9, Baculovirus cells.
Phycical Appearance Sterile Filtered colorless solution. Shipping Condition Shipped with Ice Packs.
Synonyms RetinoicAcid Receptor Responder 2; Chemerin; Retinoic Acid Receptor Responder(Tazarotene Induced) 2; Tazarotene-Induced Gene 2 Protein; RAR-ResponsiveProtein TIG2; TIG2; Retinoic Acid Receptor Responder Protein 2; HP10433; Retinoicacid receptor responder protein 2; Chemerin; RAR-responsive protein TIG2; Tazarotene-inducedgene 2 protein.
Amino Acid Sequence ADPELTEAQR RGLQVALEEFHKHPPVQWAF QETSVESAVD TPFPAGIFVR LEFKLQQTSC RKRDWKKPEC KVRPNGRKRK CLACIKLGSE DKVLGRLVHCPIETQVLREA EEHQETQCLR VQRAGEDPHS FYFPGQFAFS HHHHHH.
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Formulation RARRES2protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol.

Introduction

RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in a vast variety of tissues. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. The Chemerin receptor has another ligand, called tazarotene-induced gene.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.