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Prostaglandin E2-d9 Sale

(Synonyms: PGE2-d9; Dinoprostone-d9) 目录号 : GC47996

An internal standard for the quantification of PGE2

Prostaglandin E2-d9 Chemical Structure

Cas No.:1356347-42-6

规格 价格 库存 购买数量
50 μg
¥873.00
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100 μg
¥1,662.00
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250 μg
¥3,941.00
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500 μg
¥6,990.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

PGE2-d9 contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20' positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.5 Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.

1.Willis, A.L., and Cornelsen, M.Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain thresholdProstaglandins3(3)353-357(1973) 2.Jackson, G.M., Sharp, H.T., and Varner, M.W.Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocinAm. J. Obstet. Gynecol.171(4)1092-1096(1994) 3.Robert, A., Schultz, J.R., Nezamis, J.E., et al.Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administrationGastroenterology70(3)359-370(1976) 4.Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al.Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell linesBiochemistry34(16)5604-5609(1995) 5.Coleman, R.A., Smith, W.L., and Narumiya, S.International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypesPharmacol. Rev.46(2)205-229(1994)

Chemical Properties

Cas No. 1356347-42-6 SDF
别名 PGE2-d9; Dinoprostone-d9
Canonical SMILES O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@H](O)C1
分子式 C20H23D9O5 分子量 361.5
溶解度 DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 5 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7663 mL 13.8313 mL 27.6625 mL
5 mM 0.5533 mL 2.7663 mL 5.5325 mL
10 mM 0.2766 mL 1.3831 mL 2.7663 mL
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