(+)-Propoxyphene-d11 (hydrochloride) (CRM)
(Synonyms: Dextropropoxyphene-d11, D-Propoxyphene-d11) 目录号 : GC48603
A Certified Reference Material
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(+)-Propoxyphene-d11 (hydrochloride) (CRM) is a certified reference material intended for use as an internal standard for the quantification of (+)-propoxyphene by GC- or LC-MS. (+)-Propoxyphene is categorized as an opioid.1 It is a diphenylheptane analgesic that can have hazardous interactions with other drugs.2,1,3 Propoxyphene is regulated as a Schedule IV compound in the United States. (+)-Propoxyphene-d11 (hydrochloride) (CRM) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
1.Trescot, A.M., Datta, S., Lee, M., et al.Opioid pharmacologyPain Physician11(2 Suppl.)S133-S153(2008) 2.Codd, E.E., Shank, R.P., Schupsky, J.J., et al.Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: Structural determinants and role in antinociceptionJ. Pharmacol. Exp. Ther.274(3)1263-1270(1995) 3.Opondo, D., Eslami, S., Visscher, S., et al.Inappropriateness of medication prescriptions to elderly patients in the primary care setting: A systematic reviewPLoS One7(8)(2012)
| Cas No. | SDF | ||
| 别名 | Dextropropoxyphene-d11, D-Propoxyphene-d11 | ||
| Canonical SMILES | C[C@H](CN(C([2H])([2H])[2H])C([2H])([2H])[2H])[C@@](C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])(OC(CC)=O)CC2=CC=CC=C2.Cl | ||
| 分子式 | C22H18D11NO2•HCl | 分子量 | 387 |
| 溶解度 | 储存条件 | -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.584 mL | 12.9199 mL | 25.8398 mL |
| 5 mM | 0.5168 mL | 2.584 mL | 5.168 mL |
| 10 mM | 0.2584 mL | 1.292 mL | 2.584 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。