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Prasugrel hydrochloride Sale

(Synonyms: 盐酸普拉格雷; PCR 4099 hydrochloride) 目录号 : GC14067

A prodrug form of R-99224

Prasugrel hydrochloride Chemical Structure

Cas No.:389574-19-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥389.00
现货
5mg
¥357.00
现货
100mg
¥515.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Prasugrel hydrochloride (PCR 4099 hydrochloride) is a platelet inhibitor with IC50 value of 1.8 μM.

Prasugrel (PCR 4099) is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI[2].Prasugrel (PCR 4099) reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel hydrochloride AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 Μm[2]].

References:
[1]. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51. Epub 2007 Apr 19.
[2]. Baker WL, et al. Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes. Am J Cardiovasc Drugs. 2009;9(4):213-29.

Chemical Properties

Cas No. 389574-19-0 SDF
别名 盐酸普拉格雷; PCR 4099 hydrochloride
化学名 [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] acetate;hydrochloride
Canonical SMILES CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4.Cl
分子式 C20H21ClFNO3S 分子量 409.9
溶解度 ≥ 18.9mg/mL in DMSO with gentle warming 储存条件 -20°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4396 mL 12.1981 mL 24.3962 mL
5 mM 0.4879 mL 2.4396 mL 4.8792 mL
10 mM 0.244 mL 1.2198 mL 2.4396 mL
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