Poly-L-lysine hydrobromide (MW 150000-300000)

Poly-L-lysine (hydrobromide) (MW 150000-300000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine (hydrobromide) (MW 150000-300000) has good biocompatibility. Poly-L-lysine (hydrobromide) (MW 150000-300000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface^[1].
In Vitro, Poly-L-lysine (hydrobromide) (MW 150000-300000) binds to the hydroxyl groups on the surface of magnetic nanoparticles through its amino groups, forms a stable coating layer, prevents the agglomeration and sedimentation of magnetic nanoparticles. Poly-L-lysine (hydrobromide) (MW 150000-300000) modifies magnetic nanoparticles, improves biocompatibility, and can be used as an antibody coupling platform^[2].
Poly-L-lysine (hydrobromide) (MW 150000-300000) acts as a cationic polymer, forms a polyelectrolyte complex (PEC) with anionic methacrylated gellan gum (GG-MA), thereby forming a semipermeable membrane around the GG-MA hydrogel. Poly-L-lysine (hydrobromide) (MW 150000-300000) regulate the permeability of GG-MA/PLL PEC beads, allowing the free diffusion of small molecules while preventing the entry of large molecules, thereby achieving the immune isolation of cells^[3].

References:
[1]. D Mazia, et al. Adhesion of cells to surfaces coated with polylysine. Applications to electron microscopy. J Cell Biol. 1975 Jul;66(1):198-200.
[2]. Kubovcikova M, et al. Poly-L-lysine designed magnetic nanoparticles for combined hyperthermia, magnetic resonance imaging and cancer cell detection. Journal of Magnetism and Magnetic Materials, 2019, 475: 316-326.
[3]. Vieira S, et al., Methacrylated Gellan Gum/Poly-l-lysine Polyelectrolyte Complex Beads for Cell-Based Therapies. ACS Biomater Sci Eng. 2021 Oct 11;7(10):4898-4913.

Poly-L-lysine (hydrobromide) (MW 150000-300000) 是一种带正电荷的氨基酸聚合物，是细胞的一种非特异性附着因子。Poly-L-lysine (hydrobromide) (MW 150000-300000) 具有良好的生物相容性。Poly-L-lysine (hydrobromide) (MW 150000-300000) 通过增强细胞膜负离子与培养基表面的静电相互作用，促进细胞对固体基质的粘附^[1]。
在体外，Poly-L-lysine (hydrobromide) (MW 150000-300000) 通过其氨基与磁性纳米粒子表面的羟基结合，形成稳定的包覆层，防止磁性纳米粒子的团聚和沉降。Poly-L-lysine (hydrobromide) (MW 150000-300000) 可修饰磁性纳米粒子，提高其生物相容性，并可用作抗体偶联平台^[2]。
Poly-L-lysine (hydrobromide) (MW 150000-300000) 作为阳离子聚合物，与阴离子甲基丙烯酸酯化结冷胶 (GG-MA) 形成聚电解质复合物 (PEC)，从而在 GG-MA 水凝胶周围形成半透膜。Poly-L-lysine (hydrobromide) (MW 150000-300000) 调节GG-MA/PLL PEC珠的通透性，允许小分子自由扩散，同时阻止大分子进入，从而实现细胞的免疫隔离^[3]。