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PLSCR3 Human

目录号 : GP24197

Phospholipid Scramblase 3 Human Recombinant

PLSCR3 Human Chemical Structure

规格 价格 库存 购买数量
5μg
¥840.00
5-10工作日
25μg
¥2,030.00
5-10工作日
1mg
¥37,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

PLSCR3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-265 a.a) and having a molecular mass of 30.9kDa.

Product Data

Purity Greater than 90% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Sterile Filtered clear solution. Shipping Condition Shipped with Ice Packs.
Synonyms Phospholipid scramblase 3; PL scramblase 3; Ca(2+)-dependentphospholipid scramblase 3.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMAGYLPP KGYAPSPPPP YPVTPGYPEP ALHPGPGQAP VPAQVPAPAPGFALFPSPGP VALGSAAPFL PLPGVPSGLE FLVQIDQILI HQKAERVETF LGWETCNRYE LRSGAGQPLGQAAEESNCCA RLCCGARRPL RVRLADPGDR EVLRLLRPLH CGCSCCPCGL QEMEVQAPPG TTIGHVLQTW HPFLPKFSIQ DADRQTVLRVVGPCWTCGCG TDTNFEVKTR DESRSVGRIS KQWGGLVREA LTDADDFGLQ FPLDLDVR
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Formulation PLSCR3 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 10% glycerol and 0.4M urea.

Introduction

PhospholipidScramblase 3, (PLSCR3) may mediate accelerated ATP-independent bidirectionaltransbilayer migration of phospholipids upon binding calcium ions which resultsin a loss of phospholipid asymmetry in the plasma membrane. PLSCR3may play a key role in the initiation of fibrin clot formation, in theactivation of mast cells and in the recognition of apoptotic and injured cellsby the reticuloendothelial system. In addition, PLSCR3 seems to play a role inapoptosis, throughtranslocation of cardiolipin from the inner to the outer mitochondrial membranewhich promotes BID recruitment and enhances tBid-induced mitochondrial damages.Among the diseases associated with PLSCR3 are brain ischemia, and ischemia.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.