|Patulin 目录号 GC40483|
Sample solution is provided at 25 µL, 10mM.
|Cas No.||149-29-1||SDF||Download SDF|
|别名||Clairformin, Expansin, Mycoin C, NSC 8120, NSC 32951|
|溶解度||13mg/mL in ethanol, 10mg/mL in DMSO, 20mg/mL in DMF||储存条件||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Patulin is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium. Patulin-induced nephropathy and gastrointestinal tract malfunction have been demonstrated in several animal models. The oral LD50 value of patulin ranges between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry. The World Health Organization considers patulin cytotoxic and established a safety level of patulin in apple juice at 50 μM.2 At 100-200 μM, patulin can directly increase intracellular oxidative stress in HEK293 and HL-60 cells. In 1944, this compound was tested in a clinical trial for potential antibiotic properties to treat the common cold.
. Puel, O., Galtier, P., and Oswald, I.P. Biosynthesis and toxicological effects of patulin. Toxins 2(4), 613-631 (2010).
. Liu, B.H., Wu, T.S., Yu, F.Y., et al. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicological Sciences 95(2), 340-347 (2007).
. Chalmers, I., and Clarke, M. Commentary: The 1994 patulin trial: The first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. Int.J.Epidemiol. 32, 253-260 (2004).