Home>>Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt)

Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt)

目录号 : GC44547

An ω-alkynylated form of palmitoyl-CoA

Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt) Chemical Structure

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100μg
¥1,662.00
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250μg
¥3,941.00
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500μg
¥7,486.00
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1mg
¥13,293.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Acyl coenzyme A (acyl-CoA) thioesters are used by a variety of physiological pathways, including energy production by β-oxidation in mitochondria and peroxisomes and the biosynthesis of triacylglycerols, phospholipids, and cholesterol esters.[1]  In addition, palmitoyl CoA serves as a substrate for palmitoylation, a post-translational protein modification in which a protein acyltransferase transfers the palmitoyl group to a free thiol on target proteins. [2] Palmitoyl alkyne-CoA is an ω-alkynylated form of palmitoyl CoA. The terminal alkyne group allows the use of click chemistry linking reactions to label or pull down compounds that interact with palmitoyl CoA or, after palmitoyl transfer, the acyl group. Specifically, palmitoyl alkyne-CoA may be useful in assessing the in vitro palmitoylation of proteins.

Reference:
[1]. Waku, K. Origins and fates of fatty acyl-CoA esters. Biochim. Biophys. Acta. 1124(2), 101-111 (1992).
[2]. Budde, C., Schoenfish, M.J., Linder, M.E., et al. Purification and characterization of recombinant protein acyltransferases. Methods: A Companion to Methods in Enzymology 40(2), 143-150 (2006).

Chemical Properties

Cas No. SDF
化学名 2,2,2-trifluoroacetic acid compound with S-(2-(3-((2R)-4-(((((((2R,3S,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) hexadec-15-ynethioate
Canonical SMILES O=C(CCNC([C@@](O)([H])C(C)(C)COP(OP(O)(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1)=O)(O)=O)=O)NCCSC(CCCCCCCCCCCCCC#C)=O.FC(F)(C(O)=O)F
分子式 C37H62N7O17P3S•CF3COOH 分子量 1115.9
溶解度 10mg/mL in water 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.8961 mL 4.4807 mL 8.9614 mL
5 mM 0.1792 mL 0.8961 mL 1.7923 mL
10 mM 0.0896 mL 0.4481 mL 0.8961 mL
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