p-Hydroxyphenethyl anisate
(Synonyms: 4-甲氧基苯甲酸2-(4-羟基苯基)乙基酯,4-Hydroxyphenethyl anisate) 目录号 : GC60287
p-Hydroxyphenethyl anisate 是Notopterygium Radix 的主要活性成分。
Cas No.:87932-34-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
p-Hydroxyphenethyl anisate is a main constituent of Notopterygium Radix[1].
[1]. You-Bo Zhang, et al. Rapid and Sensitive RP-LC Method for the Quantification and Pharmacokinetic Study of p-Hydroxyphenethyl Anisate in Rat Plasma. Chromatographia 2009, 70, August.
| Cas No. | 87932-34-1 | SDF | |
| 别名 | 4-甲氧基苯甲酸2-(4-羟基苯基)乙基酯,4-Hydroxyphenethyl anisate | ||
| Canonical SMILES | O=C(OCCC1=CC=C(O)C=C1)C2=CC=C(OC)C=C2 | ||
| 分子式 | C16H16O4 | 分子量 | 272.3 |
| 溶解度 | 储存条件 | ||
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6724 mL | 18.3621 mL | 36.7242 mL |
| 5 mM | 0.7345 mL | 3.6724 mL | 7.3448 mL |
| 10 mM | 0.3672 mL | 1.8362 mL | 3.6724 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Novel glucose-responsive nanoparticles based on p-Hydroxyphenethyl anisate and 3-acrylamidophenylboronic acid reduce blood glucose and ameliorate diabetic nephropathy
Mater Today Bio 2021 Dec 3;13:100181.PMID:34927045DOI:10.1016/j.mtbio.2021.100181.
An insulin delivery system that self-regulates blood sugar levels, mimicking the human pancreas, can improve hyperglycaemia. At present, a glucose-responsive insulin delivery system combining AAPBA with long-acting slow release biomaterials has been developed. However, the safety of sustained-release materials and the challenges of preventing diabetic complications remain. In this study, we developed a novel polymer slow release material using a plant extract-p-hydroxyphenylethyl anisate (HPA). After block copolymerisation with AAPBA, the prepared nanoparticles had good pH sensitivity, glucose sensitivity, insulin loading rate and stability under physiological conditions and had high biocompatibility. The analysis of streptozotocin-induced diabetic nephropathy (DN) mouse model showed that the insulin-loaded injection of nanoparticles stably regulated the blood glucose levels of DN mice within 48 h. Importantly, with the degradation of the slow release material HPA in vivo, the renal function improved, the inflammatory response reduced, and antioxidation levels in DN mice improved. This new type of nanoparticles provides a new idea for hypoglycaemic nano-drug delivery system and may have potential in the prevention and treatment of diabetic complications.
[Chemical constituents of Notopterygium forbesii Boiss]
Zhongguo Zhong Yao Za Zhi 1996 May;21(5):295-6, 319.PMID:9388938doi
Nine compounds were isolated from the under-ground part of Notopterygium forbesii. On the basis of physicochemical properties and spectroscopic analysis, they were identified as phellopterin, isoimperattorin, notopterol, nodakenitin, nodakenin, 6-O-trans-feruoylnodakenin, p-Hydroxyphenethyl anisate, pregnenolone and beta-sitosteroi, of which phellopterin was obtained from the plant of Notopterygium genus for the first time.
[Studies on chemical constituents in roots and rhizomes of Notopterygium incisum]
Zhongguo Zhong Yao Za Zhi 2008 Dec;33(24):2918-21.PMID:19294850doi
Objective: To study the chemical constituents in the roots and rhizomes of Notopterygium incisum. Method: The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by NMR and MS evidences. Result: Twenty-four compounds were obtained and identified as isocalamenediol (1), pregnenolone (2), beta-sitosterol (3), bergapten (4), bergaptol (5), cnidilin (6), isoimperatorin (7), bergamottin (8), demethylfuropinnarin (9), nodakenetin (10), 7'-O-methylnotoptol (11), notopterol (12), notoptol (13), pabulenol (14), phenethylferulate (15), p-Hydroxyphenethyl anisate (16), trans-ferulic acid (17), nodakenin (18), sucrose (19), 2-methoxy-4-(3-methoxy-1-propenyl)-phenol (20), 3, 4, 5 trimethoxy-trans-cinnamic acid (21), p-methoxycinnamic acid (22), 4-acetoxy-3-methoxy-trans-cinnamic acid (23), and p-hydroxy-trans-cinnamic acid (24). Conclusion: Compounds 1, 14, 20-24 were isolated from the roots and rhizomes of N. incisum for the first time. Compounds 1 and 14 are sesquiterpenoid and coumarin, respectively, and 20-24 were phenylpropanoid compounds.