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O-304 Sale

目录号 : GC19269

A pan-activator of AMPK

O-304 Chemical Structure

Cas No.:1261289-04-6

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5mg
¥1,229.00
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10mg
¥1,911.00
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25mg
¥3,759.00
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50mg
¥5,807.00
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100mg
¥8,873.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

O-304 is a small molecule AMPK activator.

O-304 efficiently increases glucose uptake and reduces insulin resistance in skeletal muscle a primary cause of obesity-induced T2D. O-304 also reverses β-cell stress/dysfunction and induce β-cell rest. O-304 also increases energy expenditure and protects against diet induced obesity, fatty liver, hyperlipidemia and diabetes. CVD remains a major cause of death of T2 diabetics, and O-304 increases peripheral blood flow and left ventricular function, and acts as an "Exercise mimetic". Thus, as an AMPK activator O-304 uniquely mitigates many of the metabolic and cardiovascular complications associated with the obesity epidemic. O-304 has the unique potential to increase glucose uptake and reduce insulin resistance in newly diagnosed T2 diabetics and as such prevent the associated β-cell hyperactivity/failure and progression of the disease[1].

References:
[1]. Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes).

Chemical Properties

Cas No. 1261289-04-6 SDF
Canonical SMILES O=C(NC(SN1CC2=CC=C(Cl)C=C2)=NC1=O)C3=CC=C(Cl)C=C3
分子式 C16H11Cl2N3O2S 分子量 380.25
溶解度 DMSO : 30 mg/mL (78.90 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6298 mL 13.1492 mL 26.2985 mL
5 mM 0.526 mL 2.6298 mL 5.2597 mL
10 mM 0.263 mL 1.3149 mL 2.6298 mL
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