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(+)-Nootkatone Sale

(Synonyms: 诺卡酮; (+)-Nootkatone) 目录号 : GC40903

A natural sesquiterpene with diverse biological activity

(+)-Nootkatone Chemical Structure

Cas No.:4674-50-4

规格 价格 库存 购买数量
100mg
¥644.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

(+)-Nootkatone is sesquiterpene ketone originally isolated from grapefruit juice and peel oil with diverse biological activity. It is lethal against ticks, fleas, and mosquitoes with LC50 values of 0.0029, 0.0061, and 0.0046% w/v, respectively. Pretreatment of wood with (+)-nootkatone reduces tunnel lengths, feeding, and survival rates in C. formosanus termites. (+)-Nootkatone (10-100 µM) dose-dependently activates AMPKα1 and AMPKα2 in C2C12 mouse myoblast lysate containing a substrate peptide. It dose-dependently inhibits platelet aggregation induced by collagen, thrombin , and arachidonic acid when used at concentrations ranging from 10 to 100 μM with almost complete inhibition at the highest concentration. In vivo, (+)-nootkatone (3-30 mg/kg, p.o.) dose-dependently increases the length of tail bleeding time in mice. (+)-Nootkatone (0.1-0.3%, p.o.) dose-dependently reduces body weight and plasma glucose levels in mice fed a high-fat and high-sucrose diet.

Chemical Properties

Cas No. 4674-50-4 SDF
别名 诺卡酮; (+)-Nootkatone
Canonical SMILES CC([C@@H]1CCC2=CC(C[C@@H](C)[C@]2(C)C1)=O)=C
分子式 C15H22O 分子量 218.3
溶解度 DMF: 33 mg/ml,DMSO: 20 mg/ml,Ethanol: 33 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.5809 mL 22.9043 mL 45.8085 mL
5 mM 0.9162 mL 4.5809 mL 9.1617 mL
10 mM 0.4581 mL 2.2904 mL 4.5809 mL
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