NKX3-1 Human
目录号 : GP24049NK3 Homeobox 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A; NKX3-1; NKX3.1; NKX3A; NKX3; BAPX2. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMLRVPEP RPGEAKAEGA APPTPSKPLT SFLIQDILRD GAQRQGGRTS SQRQRDPEPE PEPEPEGGRS RAGAQNDQLS TGPRAAPEEA ETLAETEPER HLGSYLLDSE NTSGALPRLP QTPKQPQKRS RAAFSHTQVI ELERKFSHQK YLSAPERAHL AKNLKLTETQ VKIWFQNRRY KTKRKQLSSE LGDLEKHSSL PALKEEAFSR ASLVSVYNSY PYYPYLYCVG SWSPAFW. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | NKX3-1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2M UREA and 10% glycerol. | ||
NK3 Homeobox1 (NKX3-1) is a homeobox-containing transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and may act as a transcriptional repressor. The NKX3-1 transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. NKX3-1 has an imperative role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. In addition, NKX3-1 functions as a tumor suppressor controlling prostate carcinogenesis, as shown by its ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Abnormal expression of NKX3-1 is linked with prostate tumor progression.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.