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NGB Human

目录号 : GP20768

Neuroglobin Human Recombinant

NGB Human Chemical Structure

规格 价格 库存 购买数量
2μg
¥840.00
5-10工作日
10μg
¥2,030.00
5-10工作日
1mg
¥65,520.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

17kDa protein containing 151 amino acid residues of the Neuroglobin human.

Product Data

Purity Greater than 95% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Filtered White lyophilized (freeze-dried) powder. Shipping Condition Shipped at Room temp.
Synonyms NGB.
Amino Acid Sequence MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E.
Solubility Add 0.2 ml of H2O and let the lyophilized pellet dissolve completely.
Stability Store lyophilized protein at -20°C . Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C .
Formulation Filtered and lyophilized from 0.5mg/ml in 0.05M phosphate buffer, 0.1M NaCl, pH 7.2.

Introduction

Neuroglobin, 151 amino acid residue protein, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O (2) supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo, and neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucleotide and enhanced by neuroglobin overexpression.

Stability

Store lyophilized protein at -20°C . Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C .