NCS1 213 a.a. Human
目录号 : GP24020Neuronal Calcium Sensor 1 213 a.a. Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Neuronal Calcium Sensor 1; Frequenin-Like UbiquitousProtein; Frequenin-Like Protein; Frequenin Homolog; FREQ; FLUP; Frequenin(Drosophila) Homolog; Frequenin Homolog (Drosophila); FREQ; NCS-1; Neuronalcalcium sensor 1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMGKSNSK LKPEVVEELT RKTYFTEKEV QQWYKGFIKD CPSGQLDAAGFQKIYKQFFP FGDPTKFATF VFNVFDENKD GRIEFSEFIQ ALSVTSRGTL DEKLRWAFKL YDLDNDGYITRNEMLDIVDA IYQMVGNTVE LPEEENTPEK RVDRIFAMMDKNADGKLTLQ EFQEGSKADP SIVQALSLYD GLV. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | NCS1 213 a.a. protein solution (1mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl,30% glycerol and 1mM DTT. | ||
NCS1 is part of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed primarily in neurons. NCS1 regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. NCS1 is related with secretory granules and modulates synaptic transmission and synaptic plasticity. NCS1 regulates GRK1 and substitutes for calmodulin. NCS1 stimulates PI4KB kinase activity and participates in long-term synaptic plasticity through its interaction with PICK1. NCS1 takes part in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.