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NCGC00247743 Sale

目录号 : GC32896

NCGC00247743是一种组蛋白赖氨酸脱甲基酶KDM4抑制剂。

NCGC00247743 Chemical Structure

Cas No.:1435192-04-3

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10mM (in 1mL DMSO)
¥5,399.00
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5mg
¥4,909.00
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10mg
¥7,586.00
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25mg
¥14,280.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC50s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4[1].

[1]. Duan L, et al. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol. 2015 Sep 17;22(9):1185-96.

Chemical Properties

Cas No. 1435192-04-3 SDF
Canonical SMILES OC1=C(N=CC=C2)C2=CC(C3=CC(C(NCCCCCCN(C)C)=O)=CC=C3)=C1
分子式 C24H29N3O2 分子量 391.51
溶解度 DMSO : 62.5 mg/mL (159.64 mM);Water : < 0.1 mg/mL (insoluble) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.5542 mL 12.7711 mL 25.5421 mL
5 mM 0.5108 mL 2.5542 mL 5.1084 mL
10 mM 0.2554 mL 1.2771 mL 2.5542 mL
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