NABP1 Human
目录号 : GP23998Nucleic Acid Binding Protein 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Nucleic Acid Binding Protein 1; OBFC2A; Sensor OfSingle-Strand DNA Complex Subunit B2; Single-Stranded DNA-Binding Protein 2; SSB2;Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A; NucleicAcid-Binding Protein 1; Oligonucleotide/Oligosaccharide-Binding Fold-ContainingProtein 2A; Sensor Of SsDNA Subunit B2; SOSS-B2; SOSS Complex Subunit B2; hSSB2. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKVADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNPDYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | NABP1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0) 0.2M, NaCl, 50% glycerol and 2mM DTT. | ||
Nucleic acid binding protein 1 is a part of the SOSS complex, a multiprotein complexwhich functions downstream of the MRN complex to promote DNA repair and G2/Mcheckpoint. In the SOSS complex,NABP1 acts as a sensor of single-stranded DNA which binds to single-strandedDNA, in particularto polypyrimidines. The SOSS complex links with DNA lesions and affects diverse endpoints in the cellular DNA damage response including cell-cycle checkpointactivation, recombinational repair and maintenance of genomic stability. NABP1 is essential forefficient homologous recombination-dependent repair of double-strand breaks (DSBs) andATM-dependent signaling pathways.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.